Acetaminophen (Paracetamol) updated on 09-20-2024

Oro-facial clefts

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18501
R79032		 Feldkamp, 2010 Oral facial clefts 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Paracetamol use: maternal ITW/questionnaires after pregnancy 1.02 [0.90;1.15] 815/2,712   865/3,002 1,680 2,712
ref
S18505
R78749		 Rebordosa a, 2008 Orofacial clefts 1st trimester prospective cohort unexposed (general population or NOS) Adjustment: Yes Paracetamol use: maternal ITW/questionnaires during pregnancy 1.11 [0.81;1.54] 59/26,424   123/61,718 182 26,424
ref
Total 2 studies 1.03 [0.92;1.16] 1,862 29,136
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Feldkamp, 2010Feldkamp, 2010 1.02[0.90; 1.15]1,6802,71287%ROB confusion: seriousROB selection: criticalROB classification: criticalROB missing: lowROB mesure: unclearROB reporting: moderate Rebordosa a, 2008Rebordosa a, 2008 1.11[0.81; 1.54]18226,42413%ROB confusion: seriousROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 0% 1.03[0.92; 1.16]1,86229,1360.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.11[0.81; 1.53]18226,424 -NARebordosa a, 2008 1 case control studiescase control studies 1.02[0.90; 1.15]1,6802,712 -NAFeldkamp, 2010 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.03[0.92; 1.16]1,86229,1360%NAFeldkamp, 2010 Rebordosa a, 2008 2 Tags Adjustment   - Yes  - Yes 1.03[0.92; 1.16]1,86229,1360%NAFeldkamp, 2010 Rebordosa a, 2008 2 Paracetamol use   - maternal ITW/questionnaires after p ...  - maternal ITW/questionnaires after pregnancy 1.02[0.90; 1.15]1,6802,712 -NAFeldkamp, 2010 1   - maternal ITW/questionnaires during ...  - maternal ITW/questionnaires during pregnancy 1.11[0.81; 1.53]18226,424 -NARebordosa a, 2008 1 All studiesAll studies 1.03[0.92; 1.16]1,86229,1360%NAFeldkamp, 2010 Rebordosa a, 2008 20.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.03[0.92; 1.16]1,86229,1360%NAFeldkamp, 2010 Rebordosa a, 2008 20.510.01.0