Acetaminophen (Paracetamol) updated on 09-20-2024

Genital anomalies

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18505
R78759		 Rebordosa a, 2008 Genital malformations 1st trimester prospective cohort unexposed (general population or NOS) Adjustment: Yes Paracetamol use: maternal ITW/questionnaires during pregnancy 1.06 [0.82;1.37] 99/26,424   214/61,718 313 26,424
ref
Total 1 studies 1.06 [0.82;1.37] 313 26,424
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Rebordosa a, 2008Rebordosa a, 2008 1.06[0.82; 1.37]31326,4240%ROB confusion: seriousROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.06[0.82; 1.37]31326,424 -NARebordosa a, 2008 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.06[0.82; 1.37]31326,424 -NARebordosa a, 2008 1 Tags Adjustment   - Yes  - Yes 1.06[0.82; 1.37]31326,424 -NARebordosa a, 2008 1 Paracetamol use   - maternal ITW/questionnaires during ...  - maternal ITW/questionnaires during pregnancy 1.06[0.82; 1.37]31326,424 -NARebordosa a, 2008 1 All studiesAll studies 1.06[0.82; 1.37]31326,424 -NARebordosa a, 2008 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.06[0.82; 1.37]31326,424 -NARebordosa a, 2008 10.510.01.0

Umbrella review (other published meta-analyses)

Published MAControlPeriodTE95% CIn exposedkI2 Eletri (Cryptorchidism and/or hypospadias)Eletri (Cryptorchidism and/or hypospadias) 1.27[0.18; 8.94]79%-Wwhatever (meta-analysis)Anyduring pregnancy (anytime or not specified)studies TTT2 metaPregmetaPreg 1.06[0.82; 1.37]NaN%26,424----Rebordosa a, 2008 10.510.01.0