Acetaminophen (Paracetamol) updated on 09-20-2024

Limb defects

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18505
R78762		 Rebordosa a, 2008 Limb malformations 1st trimester prospective cohort unexposed (general population or NOS) Adjustment: Yes Paracetamol use: maternal ITW/questionnaires during pregnancy 1.02 [0.91;1.15] 453/26,424   1,042/61,718 1,495 26,424
ref
Total 1 studies 1.02 [0.91;1.15] 1,495 26,424
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Rebordosa a, 2008Rebordosa a, 2008 1.02[0.91; 1.15]1,49526,4240%ROB confusion: seriousROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.02[0.91; 1.15]1,49526,424 -NARebordosa a, 2008 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.02[0.91; 1.15]1,49526,424 -NARebordosa a, 2008 1 Tags Adjustment   - Yes  - Yes 1.02[0.91; 1.15]1,49526,424 -NARebordosa a, 2008 1 Paracetamol use   - maternal ITW/questionnaires during ...  - maternal ITW/questionnaires during pregnancy 1.02[0.91; 1.15]1,49526,424 -NARebordosa a, 2008 1 All studiesAll studies 1.02[0.91; 1.15]1,49526,424 -NARebordosa a, 2008 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.02[0.91; 1.15]1,49526,424 -NARebordosa a, 2008 10.510.01.0