Acetaminophen (Paracetamol) updated on 09-20-2024

Early intrauterine deaths (< 22 weeks) / Spontaneous abortions

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18573
R78922		 Li (Controls exposed to NSAIDS), 2018 Miscarriage (before 20 weeks of gestational age) during pregnancy (anytime or not specified) retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: Yes Paracetamol use: maternal ITW/questionnaires during pregnancy 0.69 [0.48;0.99]
excluded (control group) 		63/391   58/241 121 391
ref
S18572
R78921		 Li (Controls unexposed, NOS), 2018 Miscarriage (before 20 weeks of gestational age) during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes Paracetamol use: maternal ITW/questionnaires during pregnancy 1.10 [0.79;1.53] 63/391   79/465 142 391
ref
S18546
R78821		 Rebordosa, 2009 Early miscarriage (dead fetus delivered spontaneously before the 12th gestational week) 1st trimester prospective cohort unexposed (general population or NOS) Adjustment: Yes Paracetamol use: maternal ITW/questionnaires during pregnancy 1.00 [0.88;1.13] 502/-   1,942/- 2,444 -
ref
S18574
R78923		 Li, 2003 Miscarriage (natural abortion before 20 weeks of gestation) during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes Paracetamol use: maternal ITW/questionnaires during pregnancy 1.20 [0.80;1.80] 24/172   117/762 141 172
ref
Total 3 studies 1.03 [0.92;1.15] 2,727 563
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Li (Controls unexposed, NOS), 2018Li, 2018 1 1.10[0.79; 1.53]14239112%ROB confusion: seriousROB selection: lowROB classification: moderateROB missing: lowROB mesure: criticalROB reporting: moderate Rebordosa, 2009Rebordosa, 2009 1.00[0.88; 1.13]2,444-81%ROB confusion: moderateROB selection: moderateROB classification: moderateROB missing: criticalROB mesure: criticalROB reporting: moderate Li, 2003Li, 2003 1.20[0.80; 1.80]1411728%ROB confusion: seriousROB selection: lowROB classification: moderateROB missing: criticalROB mesure: criticalROB reporting: moderate Total (3 studies) I2 = 0% 1.03[0.92; 1.15]2,7275630.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, NOS;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.03[0.92; 1.15]2,7275630%NALi (Controls unexposed, NOS), 2018 Rebordosa, 2009 Li, 2003 3 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.03[0.92; 1.15]2,7275630%NALi (Controls unexposed, NOS), 2018 Rebordosa, 2009 Li, 2003 3 Tags Adjustment   - Yes  - Yes 1.03[0.92; 1.15]2,7275630%NALi (Controls unexposed, NOS), 2018 Rebordosa, 2009 Li, 2003 3 Paracetamol use   - maternal ITW/questionnaires during ...  - maternal ITW/questionnaires during pregnancy 1.03[0.92; 1.15]2,7275630%NALi (Controls unexposed, NOS), 2018 Rebordosa, 2009 Li, 2003 3 All studiesAll studies 1.03[0.92; 1.15]2,7275630%NALi (Controls unexposed, NOS), 2018 Rebordosa, 2009 Li, 2003 30.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 18573

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.03[0.92; 1.15]2,7275630%NALi (Controls unexposed, NOS), 2018 Rebordosa, 2009 Li, 2003 3 exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.69[0.48; 0.99]121391 -NALi (Controls exposed to NSAIDS), 2018 10.510.01.0