Acetaminophen (Paracetamol) updated on 09-20-2024

Late intrauterine deaths (> 22 weeks) / Stillbirths

id	Study   Auto Xu, 2024Zafeiri, 2022Rebordosa, 2009Pastore, 1999	Lib. in paper	Exposition period  Auto during pregnancy (anytime or not specified)1st trimester2nd trimester3rd trimester2nd and/or 3rd trimesterthroughout pregnancyearly pregnancydays before deliverylate pregnancypreconception-onlypericonceptionalpreconceptional for kinetic reasonat least 1st trimester3 months (or more) before pregnancy or during pregnancy1st and 2nd trimester3 months or more before pregnancy or1st trimesterPaternal exp. genotoxic window only (0–3 months preconception)Paternal exposure: epigenetic window only (3–xxx months preconception)Paternal exposure: genotoxic/epigenetic window (0–xxx months preconception)Paternal exposure: other window	Study type  All studies Case control excluded Only case control	Control type    Auto unexposed (general population or NOS)unexposed, sickunexposed, disease freeexposed to other treatment, sicknot specifiedsiblingwhatever (meta-analysis)	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S18496 R78607	Xu, 2024	Stillbirth (NOS)	during pregnancy (anytime or not specified)	retrospective cohort	unexposed (general population or NOS)	Adjustment: Yes Paracetamol use: prescription or medical files	2.29 [1.19;4.43]	41/501   24/501	65	501		ref
S18513 R78656	Zafeiri, 2022	Stillbirth	during pregnancy (anytime or not specified)	retrospective cohort	unexposed (general population or NOS)	Adjustment: Yes Paracetamol use: maternal ITW/questionnaires during pregnancy	1.52 [1.30;1.77]	275/23,979   803/106,752	1,078	23,979		ref
S18546 R78823	Rebordosa, 2009	Stillbirth (dead fetus delivered spontaneously after the 28th gestational week (>196 days))	during pregnancy (anytime or not specified)	prospective cohort	unexposed (general population or NOS)	Adjustment: Yes Paracetamol use: maternal ITW/questionnaires during pregnancy	0.90 [0.69;1.19]	98/-   111/-	209	-		ref
S18623 R79152	Pastore, 1999	Stillbirths (fetal deaths at 20 weeks' gestation or later) and infant deaths within 24 h of birth	2nd trimester	case control	unexposed (general population or NOS)	Adjustment: Yes Matched Paracetamol use: maternal ITW/questionnaires after pregnancy	0.90 [0.80;1.00]	95/219   237/470	332	219		ref
					Total	4 studies	1.21 [0.84;1.73]		1,684	24,699
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

Sensitivity analysis

Publication bias and p-hacking diagnosis

Sub-groups analysis using all included studies

excluded