Acetaminophen (Paracetamol) updated on 09-20-2024

Very preterm (28 to 32 weeks)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18546
R78828		 Rebordosa, 2009 Very preterm (<35 weeks) during pregnancy (anytime or not specified) prospective cohort unexposed (general population or NOS) Adjustment: Yes Paracetamol use: maternal ITW/questionnaires during pregnancy 0.96 [0.82;1.13] 270/-   -/- - -
ref
Total 1 studies 0.96 [0.82;1.13] 0 0
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Rebordosa, 2009Rebordosa, 2009 0.96[0.82; 1.13]--0%ROB confusion: seriousROB selection: moderateROB classification: moderateROB missing: criticalROB mesure: moderateROB reporting: moderate0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.96[0.82; 1.13]-- -NARebordosa, 2009 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.96[0.82; 1.13]-- -NARebordosa, 2009 1 Tags Adjustment   - Yes  - Yes 0.96[0.82; 1.13]-- -NARebordosa, 2009 1 Paracetamol use   - maternal ITW/questionnaires during ...  - maternal ITW/questionnaires during pregnancy 0.96[0.82; 1.13]-- -NARebordosa, 2009 1 All studiesAll studies 0.96[0.82; 1.13]-- -NARebordosa, 2009 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.96[0.82; 1.13]261- -NARebordosa, 2009 10.510.01.0