Acetaminophen (Paracetamol) updated on 09-20-2024

Small for gestational age (weight)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18594
R78996		 De Castro, 2022 Small for gestational age (birth weight below the 10th percentile for gestational age) during pregnancy (anytime or not specified) prospective cohort unexposed (general population or NOS) Adjustment: Yes Paracetamol use: maternal ITW/questionnaires during pregnancy 0.72 [0.21;1.92] 5/103   47/641 52 103
ref
S18577
R78937		 Killion, 2022 Small for gestational age - Cumulative acetaminophen use at 32 weeks 4th quintile during pregnancy (anytime or not specified) prospective cohort unexposed, sick Adjustment: Yes Paracetamol use: maternal ITW/questionnaires during pregnancy 1.10 [0.68;1.79] 31/269   42/473 73 269
ref
S16647
R69888		 Sznajder, 2022 Fetal intrauterine growth restriction during pregnancy (anytime or not specified) prospective cohort unexposed (general population or NOS) Adjustment: No Paracetamol use: maternal ITW/questionnaires during pregnancy 1.10 [0.69;1.75] C 33/1,011   42/1,411 75 1,011
ref
S18542
R79223		 Arneja, 2020 Small for gestational age (birthweight of less than the tenth centile for gestational age, relative to a Canadian reference population) throughout pregnancy prospective cohort unexposed (general population or NOS) Adjustment: Yes Paracetamol use: maternal ITW/questionnaires during pregnancy 0.80 [0.41;1.53] 20/135   96/294 116 135
ref
S18546
R78825		 Rebordosa, 2009 Small for gestational age (birth weight below the 10th percentile at a specific gestational age in weeks, based on all live singleton births of the same sex and gestational week) during pregnancy (anytime or not specified) prospective cohort unexposed (general population or NOS) Adjustment: Yes Paracetamol use: maternal ITW/questionnaires during pregnancy 0.96 [0.91;1.01] 2,590/-   3,287/- 5,877 -
ref
Total 5 studies 0.96 [0.91;1.01] 6,193 1,518
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF De Castro, 2022De Castro, 2022 0.72[0.21; 1.92]521030%ROB confusion: seriousROB selection: moderateROB classification: moderateROB missing: criticalROB mesure: moderateROB reporting: moderate Killion, 2022Killion, 2022 1.10[0.68; 1.79]732691%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Sznajder, 2022Sznajder, 2022 1.10[0.69; 1.75]751,0111%ROB confusion: seriousROB selection: lowROB classification: moderateROB missing: criticalROB mesure: moderateROB reporting: moderate Arneja, 2020Arneja, 2020 0.80[0.41; 1.53]1161351%ROB confusion: seriousROB selection: lowROB classification: moderateROB missing: moderateROB mesure: moderateROB reporting: moderate Rebordosa, 2009Rebordosa, 2009 0.96[0.91; 1.01]5,877-97%ROB confusion: seriousROB selection: moderateROB classification: moderateROB missing: criticalROB mesure: moderateROB reporting: moderate Total (5 studies) I2 = 0% 0.96[0.91; 1.01]6,1931,5180.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.96[0.91; 1.01]6,1931,5180%NADe Castro, 2022 Killion, 2022 Sznajder, 2022 Arneja, 2020 Rebordosa, 2009 5 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.96[0.91; 1.01]6,1201,2490%NADe Castro, 2022 Sznajder, 2022 Arneja, 2020 Rebordosa, 2009 4 unexposed, sickunexposed, sick 1.10[0.68; 1.78]73269 -NAKillion, 2022 1 Tags Adjustment   - No  - No 1.10[0.69; 1.75]751,011 -NASznajder, 2022 1   - Yes  - Yes 0.96[0.91; 1.01]6,1185070%NADe Castro, 2022 Killion, 2022 Arneja, 2020 Rebordosa, 2009 4 Paracetamol use   - maternal ITW/questionnaires during ...  - maternal ITW/questionnaires during pregnancy 0.96[0.91; 1.01]6,1931,5180%NADe Castro, 2022 Killion, 2022 Sznajder, 2022 Arneja, 2020 Rebordosa, 2009 5 All studiesAll studies 0.96[0.91; 1.01]6,1931,5180%NADe Castro, 2022 Killion, 2022 Sznajder, 2022 Arneja, 2020 Rebordosa, 2009 50.25.01.0

Publication bias and p-hacking diagnosis

funnel plot
0.0-1.31.30.6770.000De Castro, 2022Killion, 2022Sznajder, 2022Arneja, 2020Rebordosa, 2009

Asymetry test p-value = 0.9999 (by Egger's regression)

slope=-0.0393 (0.0204); intercept=0.0000 (0.3491); t=0.0001; p=0.9999

p values plot
0.01.00.01.0

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.96[0.91; 1.01]6,1201,2490%NADe Castro, 2022 Sznajder, 2022 Arneja, 2020 Rebordosa, 2009 4 unexposed, sick controlsunexposed, sick controls 1.10[0.68; 1.78]73269 -NAKillion, 2022 10.510.01.0

Umbrella review (other published meta-analyses)

Published MAControlPeriodTE95% CIn exposedkI2 Castro (Small for gestational age (birth weig ...Castro (Small for gestational age (birth weight <10th percentile)) Out of scale0.38[0.08; 1.87]99%-Wwhatever (meta-analysis)T33rd trimesterstudies TTT2 Castro (Small for gestational age (birth weig ...Castro (Small for gestational age (birth weight <10th percentile)) 0.69[0.50; 0.97]74%-Wwhatever (meta-analysis)Anyduring pregnancy (anytime or not specified)studies TTT2 Castro (Small for gestational age (birth weig ...Castro (Small for gestational age (birth weight <10th percentile) (high quality studies)) 0.69[0.50; 0.97]74%-Wwhatever (meta-analysis)Anyduring pregnancy (anytime or not specified)studies TTT2 metaPregmetaPreg 0.96[0.91; 1.01]0%1,518----De Castro, 2022 Killion, 2022 Sznajder, 2022 Arneja, 2020 Rebordosa, 2009 50.510.01.0