Selective Serotonin Reuptake Inhibitor (SSRI) updated on 07-01-2025

Childhood autism (F84.0)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S7554
R22598		 Viktorin b, 2017 Autistic disorder (ICD10- F84.0) at 7-8 years during pregnancy (anytime or not specified) population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes Monotherapy: no or not specified 1.04 [0.72;1.52] -/3,178   942/172,646 - 3,178
ref
S7055
R19945		 Sørensen (Controls exposed to TCA), 2013 Childhood autism (ICD-10, codes ?) - At 4-14 years (mean 8.8 years) during pregnancy (anytime or not specified) population based cohort retrospective exposed to other treatment, sick excluded Adjustment: No Monotherapy: SSRI only 1.46 [0.35;6.07] C
excluded (control group) 		34/7,506   2/642 36 7,506
ref
S479
R329		 Sørensen (Controls unexposed, NOS), 2013 Childhood autism (ICD-10, codes ?) - At 4-14 years (mean 8.8 years) during pregnancy (anytime or not specified) population based cohort retrospective unexposed (general population or NOS) excluded Adjustment: Yes Monotherapy: SSRI only 1.40 [0.90;2.00]
excluded (control group) 		34/7,506   2,030/646,782 2,064 7,506
ref
S17010
R71245		 Sørensen (Controls unexposed, sick), 2013 Childhood autism during pregnancy (anytime or not specified) population based cohort retrospective unexposed, sick Adjustment: Yes Monotherapy: SSRI only 1.00 [0.40;2.60] 7/1,475   20/4,324 27 1,475
ref
Total 2 studies 1.03 [0.73;1.46] 27 4,653
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Viktorin b, 2017Viktorin b, 2017 1.04[0.72; 1.52]-3,17886%ROB confusion: seriousROB selection: lowROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate Sørensen (Controls unexposed, sick), 2013Sørensen, 2013 1 1.00[0.40; 2.60]271,47514%ROB confusion: seriousROB selection: lowROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 0% 1.03[0.73; 1.46]274,6530.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.03[0.73; 1.46]274,6530%NAViktorin b, 2017 Sørensen (Controls unexposed, sick), 2013 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.04[0.72; 1.51]-3,178 -NAViktorin b, 2017 1 unexposed, sickunexposed, sick 1.00[0.39; 2.55]271,475 -NASørensen (Controls unexposed, sick), 2013 1 Tags Adjustment   - Yes  - Yes 1.03[0.73; 1.46]274,6530%NAViktorin b, 2017 Sørensen (Controls unexposed, sick), 2013 2 Monotherapy   - no or not specified  - no or not specified 1.04[0.72; 1.51]-3,178 -NAViktorin b, 2017 1   - SSRI only  - SSRI only 1.00[0.39; 2.55]271,475 -NASørensen (Controls unexposed, sick), 2013 1 All studiesAll studies 1.03[0.73; 1.46]274,6530%NAViktorin b, 2017 Sørensen (Controls unexposed, sick), 2013 20.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 7055, 479

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.20[0.89; 1.60]2,99710,68412%NAViktorin b, 2017 Sørensen (Controls unexposed, NOS), 2013 2 unexposed, sick controlsunexposed, sick controls 1.00[0.39; 2.55]271,475 -NASørensen (Controls unexposed, sick), 2013 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.46[0.35; 6.07]367,506 -NASørensen (Controls exposed to TCA), 2013 10.510.01.0