Selective Serotonin Reuptake Inhibitor (SSRI) updated on 07-01-2025

Gestational diabetes

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S5461
R24119		 Levy, 2020 Gestational diabetes mellitus throughout pregnancy retrospective cohort unexposed (general population or NOS) Adjustment: No Matched Monotherapy: no or not specified 2.17 [0.77;6.10] C 12/82   6/82 18 82
ref
S7443
R21982		 Dandjinou, 2019 Gestational diabetes mellitus during pregnancy (anytime or not specified) nested case control unexposed (general population or NOS) Adjustment: Yes Monotherapy: SSRI only 1.07 [0.96;1.20] 535/5,021   20,370/224,932 20,905 5,021
ref
S13017
R49393		 Hannerfors (Controls unexposed, NOS), 2015 Gestational diabetes 1st and 2nd trimester retrospective cohort unexposed (general population or NOS) excluded Adjustment: No Monotherapy: no or not specified 2.49 [0.75;8.24] C
excluded (control group) 		5/207   6/609 11 207
ref
S13016
R49385		 Hannerfors (Controls unexposed, sick), 2015 Gestational diabetes 1st and 2nd trimester retrospective cohort unexposed, sick Adjustment: No Monotherapy: no or not specified 3.03 [0.16;55.63] C 5/207   0/56 5 207
ref
S5405
R16042		 Wen, 2006 Gestational diabetes mellitus 3 months (or more) before pregnancy or during pregnancy excluded retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes Matched Monotherapy: no or not specified 1.31 [0.86;2.01]
excluded (exposition period) 		32/972   83/3,878 115 972
ref
Total 3 studies 1.17 [0.82;1.66] 20,928 5,310
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Levy, 2020Levy, 2020 2.17[0.77; 6.10]188210%ROB confusion: criticalROB selection: criticalROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Dandjinou, 2019Dandjinou, 2019 1.07[0.96; 1.20]20,9055,02188%ROB confusion: moderateROB selection: lowROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate Hannerfors (Controls unexposed, sick), 2015Hannerfors, 2015 1 3.03[0.16; 55.63]52071%ROB confusion: criticalROB selection: lowROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Total (3 studies) I2 = 12% 1.17[0.82; 1.66]20,9285,3100.510.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.25[0.85; 5.96]232890%NALevy, 2020 Hannerfors (Controls unexposed, sick), 2015 2 case control studiescase control studies 1.07[0.96; 1.20]20,9055,021 -NADandjinou, 2019 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.26[0.70; 2.24]20,9235,10344%NALevy, 2020 Dandjinou, 2019 2 unexposed, sickunexposed, sick 3.03[0.16; 55.63]5207 -NAHannerfors (Controls unexposed, sick), 2015 1 Tags Adjustment   - No  - No 2.25[0.85; 5.96]232890%NALevy, 2020 Hannerfors (Controls unexposed, sick), 2015 2   - Yes  - Yes 1.07[0.96; 1.20]20,9055,021 -NADandjinou, 2019 1 MatchedMatched 2.17[0.77; 6.10]1882 -NALevy, 2020 1 Monotherapy   - no or not specified  - no or not specified 2.25[0.85; 5.96]232890%NALevy, 2020 Hannerfors (Controls unexposed, sick), 2015 2   - SSRI only  - SSRI only 1.07[0.96; 1.20]20,9055,021 -NADandjinou, 2019 1 All studiesAll studies 1.17[0.82; 1.66]20,9285,31012%NALevy, 2020 Dandjinou, 2019 Hannerfors (Controls unexposed, sick), 2015 30.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 13017

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.43[0.81; 2.53]20,9345,31045%NALevy, 2020 Dandjinou, 2019 Hannerfors (Controls unexposed, NOS), 2015 3 unexposed, sick controlsunexposed, sick controls 3.03[0.16; 55.63]5207 -NAHannerfors (Controls unexposed, sick), 2015 10.510.01.0

Umbrella review (other published meta-analyses)

Published MAControlPeriodTE95% CIn exposedkI2 Wang (Gestational diabetes)Wang (Gestational diabetes) 1.09[0.99; 1.19]0%-Wwhatever (meta-analysis)Anyduring pregnancy (anytime or not specified)studies TTT2 metaPregmetaPreg 1.17[0.82; 1.66]12%5,310----Levy, 2020 Dandjinou, 2019 Hannerfors (Controls unexposed, sick), 2015 30.510.01.0