Selective Serotonin Reuptake Inhibitor (SSRI) updated on 07-01-2025

Ear malformations

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S495
R76912		 Källén, 2007 Severe ear malformations early pregnancy population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes Monotherapy: SSRI only 0.54 [0.27;1.07] 8/6,555   2,139/873,876 2,147 6,555
ref
Total 1 studies 0.54 [0.27;1.07] 2,147 6,555
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Källén, 2007Källén, 2007 0.54[0.27; 1.07]2,1476,5550%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: lowROB mesure: unclearROB reporting: moderate0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.54[0.27; 1.07]2,1476,555 -NAKällén, 2007 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.54[0.27; 1.07]2,1476,555 -NAKällén, 2007 1 Tags Adjustment   - Yes  - Yes 0.54[0.27; 1.07]2,1476,555 -NAKällén, 2007 1 Monotherapy   - SSRI only  - SSRI only 0.54[0.27; 1.07]2,1476,555 -NAKällén, 2007 1 All studiesAll studies 0.54[0.27; 1.07]2,1476,555 -NAKällén, 2007 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.54[0.27; 1.07]2,1476,555 -NAKällén, 2007 10.510.01.0