Selective Serotonin Reuptake Inhibitor (SSRI) updated on 07-01-2025

Multicystic renal dysplasia

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S516
R15363		 Furu (Controls unexposed, NOS), 2015 Cystic kidneys (Q61.0-Q61.8) 1st trimester population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes Monotherapy: SSRI only 1.15 [0.68;1.94] 15/36,772   834/2,266,875 849 36,772
ref
S7348
R21409		 Wemakor, 2015 Renal Dysplasia 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Monotherapy: SSRI only 3.01 [1.61;5.61] 12/111   606/17,590 618 111
ref
Total 2 studies 1.83 [0.71;4.70] 1,467 36,883
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Furu (Controls unexposed, NOS), 2015Furu, 2015 1 1.15[0.68; 1.94]84936,77252%ROB confusion: criticalROB selection: moderateROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Wemakor, 2015Wemakor, 2015 3.01[1.61; 5.61]61811148%ROB confusion: criticalROB selection: criticalROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 81% 1.83[0.71; 4.70]1,46736,8830.510.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, NOS;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.15[0.68; 1.94]84936,772 -NAFuru (Controls unexposed, NOS), 2015 1 case control studiescase control studies 3.01[1.61; 5.62]618111 -NAWemakor, 2015 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.83[0.71; 4.70]1,46736,88381%NAFuru (Controls unexposed, NOS), 2015 Wemakor, 2015 2 Tags Adjustment   - Yes  - Yes 1.83[0.71; 4.70]1,46736,88381%NAFuru (Controls unexposed, NOS), 2015 Wemakor, 2015 2 Monotherapy   - SSRI only  - SSRI only 1.83[0.71; 4.70]1,46736,88381%NAFuru (Controls unexposed, NOS), 2015 Wemakor, 2015 2 All studiesAll studies 1.83[0.71; 4.70]1,46736,88381%NAFuru (Controls unexposed, NOS), 2015 Wemakor, 2015 20.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.83[0.71; 4.70]1,46736,88381%NAFuru (Controls unexposed, NOS), 2015 Wemakor, 2015 20.510.01.0

Umbrella review (other published meta-analyses)

Published MAControlPeriodTE95% CIn exposedkI2 Gao - SSRI (Cystic kidney disease)Gao - SSRI (Cystic kidney disease) Out of scale2.96[1.87; -9.00]-U,GPunexposed (general population or NOS)T11st trimesterstudies TTT3 metaPregmetaPreg 1.83[0.71; 4.70]81%36,883----Furu (Controls unexposed, NOS), 2015 Wemakor, 2015 20.510.01.0