Selective Serotonin Reuptake Inhibitor (SSRI) updated on 07-01-2025

Transposition of the great vessels

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S7467
R22085		 Anderson, 2020 Transposition of the great arteries 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Monotherapy: SSRI only 1.23 [0.83;1.81] -/-   0/- - -
ref
S7348
R21419		 Wemakor, 2015 Transposition of great vessels (complete) 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Monotherapy: SSRI only 0.79 [0.25;2.52] 3/102   612/17,596 615 102
ref
S497
R16466		 Malm, 2011 Transposition of the great vessels 1st trimester population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes Monotherapy: no or not specified 0.60 [0.15;2.52] 2/6,976   238/628,607 240 6,976
ref
Total 3 studies 1.13 [0.79;1.61] 855 7,078
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Anderson, 2020Anderson, 2020 1.23[0.83; 1.81]--84%ROB confusion: seriousROB selection: criticalROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Wemakor, 2015Wemakor, 2015 0.79[0.25; 2.52]61510210%ROB confusion: criticalROB selection: criticalROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Malm, 2011Malm, 2011 0.60[0.15; 2.52]2406,9766%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Total (3 studies) I2 = 0% 1.13[0.79; 1.61]8557,0780.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.60[0.15; 2.46]2406,976 -NAMalm, 2011 1 case control studiescase control studies 1.18[0.81; 1.70]6151020%NAAnderson, 2020 Wemakor, 2015 2 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.13[0.79; 1.61]8557,0780%NAAnderson, 2020 Wemakor, 2015 Malm, 2011 3 Tags Adjustment   - Yes  - Yes 1.13[0.79; 1.61]8557,0780%NAAnderson, 2020 Wemakor, 2015 Malm, 2011 3 Monotherapy   - no or not specified  - no or not specified 0.60[0.15; 2.46]2406,976 -NAMalm, 2011 1   - SSRI only  - SSRI only 1.18[0.81; 1.70]6151020%NAAnderson, 2020 Wemakor, 2015 2 All studiesAll studies 1.13[0.79; 1.61]8557,0780%NAAnderson, 2020 Wemakor, 2015 Malm, 2011 30.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.13[0.79; 1.61]8557,0780%NAAnderson, 2020 Wemakor, 2015 Malm, 2011 30.510.01.0