Selective Serotonin Reuptake Inhibitor (SSRI) updated on 07-01-2025

Hypoplastic left heart (HLH/HLHS)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S7467
R22093		 Anderson, 2020 Hypoplastic left heart syndrome 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Monotherapy: SSRI only 1.55 [1.05;2.30] -/-   0/- - -
ref
S7348
R21426		 Wemakor, 2015 Hypoplastic left heart 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Monotherapy: SSRI only 1.22 [0.38;3.88] 3/102   395/17,379 398 102
ref
S11325
R41722		 Louik, 2014 Hypoplastic left heart syndrome 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Monotherapy: no or not specified 1.10 [0.50;2.20] 8/298   273/8,594 281 298
ref
S493
R15252		 Colvin, 2011 Hypoplastic left heart syndrome 1st trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: No Monotherapy: no or not specified 2.26 [0.82;6.22] -/2,701   62/94,561 - 2,701
ref
Total 4 studies 1.48 [1.08;2.04] 679 3,101
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Anderson, 2020Anderson, 2020 1.55[1.05; 2.30]--65%ROB confusion: seriousROB selection: criticalROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Wemakor, 2015Wemakor, 2015 1.22[0.38; 3.88]3981027%ROB confusion: criticalROB selection: criticalROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Louik, 2014Louik, 2014 1.10[0.50; 2.20]28129818%ROB confusion: moderateROB selection: criticalROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Colvin, 2011Colvin, 2011 2.26[0.82; 6.22]-2,70110%ROB confusion: criticalROB selection: moderateROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate Total (4 studies) I2 = 0% 1.48[1.08; 2.04]6793,1010.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.26[0.82; 6.22]-2,701 -NAColvin, 2011 1 case control studiescase control studies 1.42[1.02; 1.98]6794000%NAAnderson, 2020 Wemakor, 2015 Louik, 2014 3 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.48[1.08; 2.04]6793,1010%NAAnderson, 2020 Wemakor, 2015 Louik, 2014 Colvin, 2011 4 Tags Adjustment   - No  - No 2.26[0.82; 6.22]-2,701 -NAColvin, 2011 1   - Yes  - Yes 1.42[1.02; 1.98]6794000%NAAnderson, 2020 Wemakor, 2015 Louik, 2014 3 Monotherapy   - no or not specified  - no or not specified 1.45[0.73; 2.87]2812,99921%NALouik, 2014 Colvin, 2011 2   - SSRI only  - SSRI only 1.51[1.04; 2.19]3981020%NAAnderson, 2020 Wemakor, 2015 2 All studiesAll studies 1.48[1.08; 2.04]6793,1010%NAAnderson, 2020 Wemakor, 2015 Louik, 2014 Colvin, 2011 40.55.01.0

Publication bias and p-hacking diagnosis

funnel plot
0.0-1.41.80.7110.000Anderson, 2020Wemakor, 2015Louik, 2014Colvin, 2011

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot
0.01.00.01.0

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.48[1.08; 2.04]7323,1010%NAAnderson, 2020 Wemakor, 2015 Louik, 2014 Colvin, 2011 40.510.01.0