Selective Serotonin Reuptake Inhibitor (SSRI) updated on 07-01-2025

Ebstein's anomaly

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S7467
R22099		 Anderson, 2020 Ebstein anomaly 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Monotherapy: SSRI only 0.80 [0.29;2.17] -/-   0/- - -
ref
S13343
R51444		 Boyle, 2017 Ebstein’s anomaly 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Monotherapy: SSRI only 5.39 [1.96;14.80] 4/238   169/50,959 173 238
ref
Total 2 studies 2.08 [0.32;13.46] 173 238
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Anderson, 2020Anderson, 2020 0.80[0.29; 2.17]--50%ROB confusion: seriousROB selection: criticalROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Boyle, 2017Boyle, 2017 5.39[1.96; 14.80]17323850%ROB confusion: criticalROB selection: criticalROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 85% 2.08[0.32; 13.46]1732380.220.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 2.08[0.32; 13.46]17323885%NAAnderson, 2020 Boyle, 2017 2 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 2.08[0.32; 13.46]17323885%NAAnderson, 2020 Boyle, 2017 2 Tags Adjustment   - Yes  - Yes 2.08[0.32; 13.46]17323885%NAAnderson, 2020 Boyle, 2017 2 Monotherapy   - SSRI only  - SSRI only 2.08[0.32; 13.46]17323885%NAAnderson, 2020 Boyle, 2017 2 All studiesAll studies 2.08[0.32; 13.46]17323885%NAAnderson, 2020 Boyle, 2017 20.220.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 2.08[0.32; 13.46]17323885%NAAnderson, 2020 Boyle, 2017 20.510.01.0