Selective Serotonin Reuptake Inhibitor (SSRI) updated on 07-01-2025

Necrotizing enterocolitis

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S5461
R24133		 Levy, 2020 Necrotizing enterocolitis throughout pregnancy retrospective cohort unexposed (general population or NOS) Adjustment: No Matched Monotherapy: no or not specified 1.00 [0.02;51.01] C 0/82   0/82 0 82
ref
S8046
R24479		 Batton, 2013 Necrotizing enterocolitis during pregnancy (anytime or not specified) retrospective cohort unexposed, disease free Adjustment: No Monotherapy: SSRI only 0.21 [0.02;2.07] C 1/19   4/19 5 19
ref
Total 2 studies 0.31 [0.04;2.25] 5 101
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Levy, 2020Levy, 2020 1.00[0.02; 51.01]08225%ROB confusion: criticalROB selection: criticalROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Batton, 2013Batton, 2013 0.21[0.02; 2.07]51975%ROB confusion: criticalROB selection: moderateROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 0% 0.31[0.04; 2.25]51010.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.31[0.04; 2.25]51010%NALevy, 2020 Batton, 2013 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.31[0.04; 2.25]51010%NALevy, 2020 Batton, 2013 2 Tags Adjustment   - No  - No 0.31[0.04; 2.25]51010%NALevy, 2020 Batton, 2013 2 MatchedMatched 1.00[0.02; 51.01]-82 -NALevy, 2020 1 Monotherapy   - no or not specified  - no or not specified 1.00[0.02; 51.01]-82 -NALevy, 2020 1   - SSRI only  - SSRI only 0.21[0.02; 2.07]519 -NABatton, 2013 1 All studiesAll studies 0.31[0.04; 2.25]51010%NALevy, 2020 Batton, 2013 20.110.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) Out of scale0.31[0.04; 2.25]51010%NALevy, 2020 Batton, 2013 20.510.01.0