Misoprostol

Limb reduction defects (LRD)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S2277
R3133		 Orioli, 2000 Terminal transverse limb reduction 1st trimester case control Adjustment: No 12.04 [3.52;41.12] 3/34   31/4,639 34 34
ref
S2836
R3810		 Vargas, 2000 transverse limb reduction defect 1st trimester case control Matched 24.00 [3.00;99.10] 9/13   18/95 27 13
ref
Total 2 studies 15.12 [5.53;41.34] 61 47
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Orioli, 2000Orioli, 2000 12.04[3.52; 41.12]343467%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Vargas, 2000Vargas, 2000 24.00[3.00; 99.10]271333%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 0% 15.12[5.53; 41.34]61470.950.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 15.12[5.53; 41.34]61470%NAOrioli, 2000 Vargas, 2000 2 Type of controls Tags Adjustment   - No  - No 12.04[3.52; 41.15]3434 -NAOrioli, 2000 1 MatchedMatched 24.00[4.18; 137.94]2713 -NAVargas, 2000 1 All studiesAll studies 15.12[5.53; 41.34]61470%NAOrioli, 2000 Vargas, 2000 20.550.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls 0.510.01.0