Misoprostol

Moebius syndrome

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S2836
R3809		 Vargas, 2000 Moebius sequence 1st trimester case control Matched 49.00 [7.07;1907.00] 18/24   11/92 29 24
ref
S2523
R3389		 Pastuszak, 1998 Moebius syndrome 1st trimester case control Adjustment: No 29.73 [8.80;100.45] C 47/50   49/142 96 50
ref
Total 2 studies 32.19 [10.54;98.31] 125 74
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Vargas, 2000Vargas, 2000 49.00[7.07; 1907.00]292416%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Pastuszak, 1998Pastuszak, 1998 29.73[8.80; 100.45]965084%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 0% 32.19[10.54; 98.31]125740.9100.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 32.19[10.54; 98.31]125740%NAVargas, 2000 Pastuszak, 1998 2 Type of controls Tags Adjustment   - No  - No 29.73[8.80; 100.45]9650 -NAPastuszak, 1998 1 MatchedMatched 49.00[2.98; 804.75]2924 -NAVargas, 2000 1 All studiesAll studies 32.19[10.54; 98.31]125740%NAVargas, 2000 Pastuszak, 1998 20.5100.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls 0.510.01.0