Misoprostol

Major congenital malformations

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3067
R4680		 Auffret, 2016 Major malformations 1st trimester prospective cohort unexposed, disease free Adjustment: No 3.12 [0.94;10.32] C 9/159   4/212 13 159
ref
S2262
R2600		 Vauzelle, 2013 major malformations 1st trimester prospective cohort unexposed, disease free Adjustment: No 2.20 [0.90;7.70] 6/152   4/218 10 152
ref
S2263
R2605		 Barbero, 2011 Major malformations 1st trimester prospective cohort exposed to other treatment, sick Adjustment: Yes 3.80 [1.05;14.61] 5/77   8/372 13 77
ref
S2273
R2638		 Opaleye, 2010 Congenital anomalies during pregnancy (anytime or not specified) excluded case control Adjustment: No 3.65 [0.74;17.91]
excluded (exposition period) 		7/9   112/234 119 9
ref
Total 3 studies 2.86 [1.44;5.65] 36 388
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Auffret, 2016Auffret, 2016 3.12[0.94; 10.32]1315933%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Vauzelle, 2013Vauzelle, 2013 2.20[0.90; 7.70]1015240%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Barbero, 2011Barbero, 2011 3.80[1.05; 14.61]137727%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (3 studies) I2 = 0% 2.86[1.44; 5.65]363880.910.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.86[1.44; 5.65]363880%NAAuffret, 2016 Vauzelle, 2013 Barbero, 2011 3 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 2.57[1.16; 5.72]233110%NAAuffret, 2016 Vauzelle, 2013 2 exposed to other treatment, sickexposed to other treatment, sick 3.80[1.02; 14.17]1377 -NABarbero, 2011 1 Tags Adjustment   - No  - No 2.57[1.16; 5.72]233110%NAAuffret, 2016 Vauzelle, 2013 2   - Yes  - Yes 3.80[1.02; 14.17]1377 -NABarbero, 2011 1 All studiesAll studies 2.86[1.44; 5.65]363880%NAAuffret, 2016 Vauzelle, 2013 Barbero, 2011 30.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 2.57[1.16; 5.72]233110%NAAuffret, 2016 Vauzelle, 2013 2 exposed to other treatment, sick controlsexposed to other treatment, sick controls 3.80[1.02; 14.17]1377 -NABarbero, 2011 10.510.01.0