Misoprostol

Early intrauterine death (< 22 weeks)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3005
R4287		 Andersen (vs diclofenac), 2016 Miscarriage 1st trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes 2.50 [1.80;3.50] -/166   -/5,911 - 166
ref
S2267
R2768		 Andersen (vs unexposed), 2016 Miscarriage 1st trimester retrospective cohort (claims database) unexposed (general population or NOS) excluded Adjustment: Yes Monotherapy 3.60 [2.60;4.90]
excluded (control group) 		47/166   142,100/1,338,658 142,147 166
ref
S2262
R2601		 Vauzelle, 2013 spontaneous abortions 1st trimester prospective cohort unexposed, disease free Adjustment: No 1.54 [0.78;3.06] 16/130   20/240 36 130
ref
Total 2 studies 2.16 [1.40;3.34] 36 296
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Andersen (vs diclofenac), 2016Andersen, 2016 1 2.50[1.80; 3.50]-16670%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Vauzelle, 2013Vauzelle, 2013 1.54[0.78; 3.06]3613030%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 36% 2.16[1.40; 3.34]362960.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: vs diclofenac;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.16[1.40; 3.34]3629636%NAAndersen (vs diclofenac), 2016 Vauzelle, 2013 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 2.16[1.40; 3.34]3629636%NAAndersen (vs diclofenac), 2016 Vauzelle, 2013 2 Tags Adjustment   - No  - No 1.54[0.78; 3.05]36130 -NAVauzelle, 2013 1   - Yes  - Yes 2.50[1.79; 3.49]-166 -NAAndersen (vs diclofenac), 2016 1 All studiesAll studies 2.16[1.40; 3.34]3629636%NAAndersen (vs diclofenac), 2016 Vauzelle, 2013 20.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 2267, 2267

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 2.61[1.74; 3.91]142,18346265%NAAndersen (vs diclofenac), 2016 Andersen (vs unexposed), 2016 Vauzelle, 2013 30.510.01.0