Aripiprazole updated on 06-10-2025

Gestational diabetes

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S14444
R57302		 Wang - UK cohort, 2021 Gestational diabetes mellitus (GDM; using Read Code classification or a recorded fasting plasma glucose level of 5.6 mmol/l or above or a 2-h plasma glucose level of 7.8 mmol/l or above) during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed, sick Adjustment: Yes 4.66 [0.87;25.03] -/-   40/1,577 - -
ref
S3188
R5105		 Park, 2018 Gestational diabetes at least 1st trimester retrospective cohort (claims database) unexposed, sick Adjustment: Yes 0.82 [0.50;1.33] 20/419   68/1,505 88 419
ref
S2399
R3018		 Bellet, 2015 Gestational diabetes 1st trimester prospective cohort unexposed (general population or NOS) Adjustment: No 1.15 [0.33;4.04] 4/86   7/172 11 86
ref
Total 3 studies 1.24 [0.53;2.92] 99 505
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Wang - UK cohort, 2021Wang - UK cohort, 2021 4.66[0.87; 25.03]--19%ROB confusion: moderateROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Park, 2018Park, 2018 0.82[0.50; 1.33]8841954%ROB confusion: moderateROB selection: lowROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Bellet, 2015Bellet, 2015 1.15[0.33; 4.04]118627%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: moderateROB mesure: unclearROB reporting: moderate Total (3 studies) I2 = 48% 1.24[0.53; 2.92]995050.210.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.24[0.53; 2.92]9950548%NAWang - UK cohort, 2021 Park, 2018 Bellet, 2015 3 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.15[0.33; 4.02]1186 -NABellet, 2015 1 unexposed, sickunexposed, sick 1.61[0.31; 8.47]8841974%NAWang - UK cohort, 2021 Park, 2018 2 Tags Adjustment   - No  - No 1.15[0.33; 4.02]1186 -NABellet, 2015 1   - Yes  - Yes 1.61[0.31; 8.47]8841974%NAWang - UK cohort, 2021 Park, 2018 2 All studiesAll studies 1.24[0.53; 2.92]9950548%NAWang - UK cohort, 2021 Park, 2018 Bellet, 2015 30.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.15[0.33; 4.02]1186 -NABellet, 2015 1 unexposed, sick controlsunexposed, sick controls 1.61[0.31; 8.47]11941974%NAWang - UK cohort, 2021 Park, 2018 20.510.01.0