Aripiprazole updated on 06-10-2025

Limb reduction defects (LRD)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S14302
R56385		 Huybrechts (Controls unexposed, NOS), 2023 Limb reduction Defect 1st trimester population based cohort retrospective unexposed (general population or NOS) excluded Adjustment: Yes 2.78 [0.90;8.63]
excluded (control group) 		-/4,523   -/6,455,324 - 4,523
ref
S14303
R56397		 Huybrechts (Controls unexposed, sick), 2023 Limb reduction Defect 1st trimester population based cohort retrospective unexposed, sick Adjustment: Yes 2.04 [0.51;8.15] -/3,861   -/318,731 - 3,861
ref
Total 1 studies 2.04 [0.51;8.15] 0 3,861
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Huybrechts (Controls unexposed, sick), 2023Huybrechts, 2023 1 2.04[0.51; 8.15]-3,8610%ROB confusion: moderateROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: unclearROB reporting: moderate0.95.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.04[0.51; 8.15]-3,861 -NAHuybrechts (Controls unexposed, sick), 2023 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 2.04[0.51; 8.15]-3,861 -NAHuybrechts (Controls unexposed, sick), 2023 1 Tags Adjustment   - Yes  - Yes 2.04[0.51; 8.15]-3,861 -NAHuybrechts (Controls unexposed, sick), 2023 1 All studiesAll studies 2.04[0.51; 8.15]-3,861 -NAHuybrechts (Controls unexposed, sick), 2023 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 14302

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 2.78[0.90; 8.61]-4,523 -NAHuybrechts (Controls unexposed, NOS), 2023 1 unexposed, sick controlsunexposed, sick controls 2.04[0.51; 8.15]-3,861 -NAHuybrechts (Controls unexposed, sick), 2023 10.510.01.0