Aripiprazole updated on 06-10-2025

Ano-rectal atresia and stenosis

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S14302
R56386		 Huybrechts (Controls unexposed, NOS), 2023 Anorectal Atresia/Stenosis 1st trimester population based cohort retrospective unexposed (general population or NOS) excluded Adjustment: Yes 0.37 [0.05;2.62]
excluded (control group) 		-/4,523   -/6,455,324 - 4,523
ref
S14303
R56398		 Huybrechts (Controls unexposed, sick), 2023 Anorectal Atresia/Stenosis 1st trimester population based cohort retrospective unexposed, sick Adjustment: Yes 0.42 [0.06;3.01] -/3,861   -/318,731 - 3,861
ref
S2479
R3249		 Raguideau, 2017 Ano-rectal atresia early pregnancy retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: No 2.08 [0.13;33.34] C 0/790   574/1,888,130 574 790
ref
Total 2 studies 0.72 [0.14;3.54] 574 4,651
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Huybrechts (Controls unexposed, sick), 2023Huybrechts, 2023 1 0.42[0.06; 3.01]-3,86167%ROB confusion: moderateROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: unclearROB reporting: moderate Raguideau, 2017Raguideau, 2017 2.08[0.13; 33.34]57479033%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 0% 0.72[0.14; 3.54]5744,6510.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.72[0.14; 3.54]5744,6510%NAHuybrechts (Controls unexposed, sick), 2023 Raguideau, 2017 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 2.08[0.13; 33.34]574790 -NARaguideau, 2017 1 unexposed, sickunexposed, sick 0.42[0.06; 2.97]-3,861 -NAHuybrechts (Controls unexposed, sick), 2023 1 Tags Adjustment   - No  - No 2.08[0.13; 33.34]574790 -NARaguideau, 2017 1   - Yes  - Yes 0.42[0.06; 2.97]-3,861 -NAHuybrechts (Controls unexposed, sick), 2023 1 All studiesAll studies 0.72[0.14; 3.54]5744,6510%NAHuybrechts (Controls unexposed, sick), 2023 Raguideau, 2017 20.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 14302

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.66[0.13; 3.32]5745,3130%NAHuybrechts (Controls unexposed, NOS), 2023 Raguideau, 2017 2 unexposed, sick controlsunexposed, sick controls Out of scale0.42[0.06; 2.97]-3,861 -NAHuybrechts (Controls unexposed, sick), 2023 10.510.01.0