Aripiprazole updated on 06-10-2025

Gastroschisis

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S14302
R56387		 Huybrechts (Controls unexposed, NOS), 2023 Gastroschisis 1st trimester population based cohort retrospective unexposed (general population or NOS) excluded Adjustment: Yes 1.22 [0.39;3.79]
excluded (control group) 		-/4,523   -/6,455,324 - 4,523
ref
S14303
R56399		 Huybrechts (Controls unexposed, sick), 2023 Gastroschisis 1st trimester population based cohort retrospective unexposed, sick Adjustment: Yes 0.48 [0.07;3.44] -/3,861   -/318,731 - 3,861
ref
S2479
R3254		 Raguideau, 2017 Laparoschisis early pregnancy retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: No 9.80 [0.20;55.50] 1/790   246/1,888,130 247 790
ref
Total 2 studies 1.82 [0.10;34.19] 247 4,651
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Huybrechts (Controls unexposed, sick), 2023Huybrechts, 2023 1 0.48[0.07; 3.44]-3,86156%ROB confusion: moderateROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: unclearROB reporting: moderate Raguideau, 2017Raguideau, 2017 9.80[0.20; 55.50]24779044%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 67% 1.82[0.10; 34.19]2474,6510.220.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.82[0.10; 34.19]2474,65167%NAHuybrechts (Controls unexposed, sick), 2023 Raguideau, 2017 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 9.80[0.59; 163.25]247790 -NARaguideau, 2017 1 unexposed, sickunexposed, sick 0.48[0.07; 3.36]-3,861 -NAHuybrechts (Controls unexposed, sick), 2023 1 Tags Adjustment   - No  - No 9.80[0.59; 163.25]247790 -NARaguideau, 2017 1   - Yes  - Yes 0.48[0.07; 3.36]-3,861 -NAHuybrechts (Controls unexposed, sick), 2023 1 All studiesAll studies 1.82[0.10; 34.19]2474,65167%NAHuybrechts (Controls unexposed, sick), 2023 Raguideau, 2017 20.220.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 14302

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 2.29[0.35; 14.90]2475,31345%NAHuybrechts (Controls unexposed, NOS), 2023 Raguideau, 2017 2 unexposed, sick controlsunexposed, sick controls Out of scale0.48[0.07; 3.36]-3,861 -NAHuybrechts (Controls unexposed, sick), 2023 10.510.01.0