Aripiprazole updated on 06-10-2025

Cognitive developmental disorders/delay (> 6 years old)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18361
R77636		 Bruno, 2024 Cognitive developmental disorders/delay (ICD-10 codes F70.0–F73.0) - Median follow-up: 6.7 years during pregnancy (anytime or not specified) population based cohort retrospective unexposed, sick Adjustment: Yes 1.66 [0.76;3.64] -/523   869/197,296 - 523
ref
S12476
R77642		 Straub, 2022 Intellectual disability (≥ 2 dates with ICD-9 Dx 317, 318.x, 319) - By 8 years of age early pregnancy retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes 1.40 [0.60;3.27] -/-   3,348/2,002,687 - -
ref
Total 2 studies 1.53 [0.86;2.73] 0 523
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Bruno, 2024Bruno, 2024 1.66[0.76; 3.64]-52354%ROB confusion: seriousROB selection: lowROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Straub, 2022Straub, 2022 1.40[0.60; 3.27]--46%ROB confusion: moderateROB selection: lowROB classification: criticalROB missing: unclearROB mesure: criticalROB reporting: moderate Total (2 studies) I2 = 0% 1.53[0.86; 2.73]-5230.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.53[0.86; 2.73]-5230%NABruno, 2024 Straub, 2022 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.40[0.60; 3.27]-- -NAStraub, 2022 1 unexposed, sickunexposed, sick 1.66[0.76; 3.63]-523 -NABruno, 2024 1 Tags Adjustment   - Yes  - Yes 1.53[0.86; 2.73]-5230%NABruno, 2024 Straub, 2022 2 All studiesAll studies 1.53[0.86; 2.73]-5230%NABruno, 2024 Straub, 2022 20.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.40[0.60; 3.27]3,339- -NAStraub, 2022 1 unexposed, sick controlsunexposed, sick controls 1.66[0.76; 3.63]860523 -NABruno, 2024 10.510.01.0