Aripiprazole updated on 06-10-2025

Respiratory system anomalies

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S12156
R45062		 Ellfolk (Controls exposed to FGA), 2021 Respiratory tract malformations (ICD-9; 748) 1st trimester population based cohort retrospective exposed to other treatment, sick excluded Adjustment: No 0.94 [0.04;19.57] C
excluded (control group) 		0/220   2/1,030 2 220
ref
S12155
R45054		 Ellfolk (Controls unexposed NOS), 2021 Respiratory tract malformations (ICD-9; 748) 1st trimester population based cohort retrospective unexposed (general population or NOS) Adjustment: No Matched 2.50 [0.15;41.51] C 0/220   20/22,540 20 220
ref
Total 1 studies 2.50 [0.15;41.51] 20 220
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Ellfolk (Controls unexposed NOS), 2021Ellfolk, 2021 1 2.50[0.15; 41.51]202200%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: moderateROB mesure: moderateROB reporting: moderate0.910.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed NOS;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.50[0.15; 41.51]20220 -NAEllfolk (Controls unexposed NOS), 2021 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 2.50[0.15; 41.51]20220 -NAEllfolk (Controls unexposed NOS), 2021 1 Tags Adjustment   - No  - No 2.50[0.15; 41.51]20220 -NAEllfolk (Controls unexposed NOS), 2021 1 MatchedMatched 2.50[0.15; 41.51]20220 -NAEllfolk (Controls unexposed NOS), 2021 1 All studiesAll studies 2.50[0.15; 41.51]20220 -NAEllfolk (Controls unexposed NOS), 2021 10.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 12156

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 2.50[0.15; 41.51]20220 -NAEllfolk (Controls unexposed NOS), 2021 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.94[0.04; 19.57]2220 -NAEllfolk (Controls exposed to FGA), 2021 10.510.01.0