Aripiprazole updated on 06-10-2025

Oro-facial clefts

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S14302
R56382		 Huybrechts (Controls unexposed, NOS), 2023 Oral Cleft 1st trimester population based cohort retrospective unexposed (general population or NOS) excluded Adjustment: Yes 0.91 [0.43;1.91]
excluded (control group) 		-/4,523   -/6,455,324 - 4,523
ref
S14303
R56394		 Huybrechts (Controls unexposed, sick), 2023 Oral Cleft 1st trimester population based cohort retrospective unexposed, sick Adjustment: Yes 0.66 [0.27;1.58] -/3,861   -/318,731 - 3,861
ref
Total 1 studies 0.66 [0.27;1.60] 0 3,861
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Huybrechts (Controls unexposed, sick), 2023Huybrechts, 2023 1 0.66[0.27; 1.58]-3,8610%ROB confusion: moderateROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: unclearROB reporting: moderate0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.66[0.27; 1.60]-3,861 -NAHuybrechts (Controls unexposed, sick), 2023 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 0.66[0.27; 1.60]-3,861 -NAHuybrechts (Controls unexposed, sick), 2023 1 Tags Adjustment   - Yes  - Yes 0.66[0.27; 1.60]-3,861 -NAHuybrechts (Controls unexposed, sick), 2023 1 All studiesAll studies 0.66[0.27; 1.60]-3,861 -NAHuybrechts (Controls unexposed, sick), 2023 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 14302

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.91[0.43; 1.92]-4,523 -NAHuybrechts (Controls unexposed, NOS), 2023 1 unexposed, sick controlsunexposed, sick controls 0.66[0.27; 1.60]-3,861 -NAHuybrechts (Controls unexposed, sick), 2023 10.510.01.0