Aripiprazole updated on 06-10-2025

Early intrauterine deaths (< 22 weeks) / Spontaneous abortions

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18354
R77402		 Ishikawa, 2024 Miscarriage (4 - 22 weeks of gestation) during pregnancy (anytime or not specified) nested case control unexposed (general population or NOS) Adjustment: Yes 1.00 [0.78;1.27] 108/405   44,010/176,030 44,118 405
ref
S2399
R3020		 Bellet, 2015 Miscarriage (spontaneous abortion before 22 GW) 1st trimester prospective cohort unexposed (general population or NOS) Adjustment: No 1.66 [0.63;4.38] 8/86   10/172 18 86
ref
S2438
R3081		 Sorensen, 2015 Spontaneous abortion (< 22 weeks) early pregnancy population based cohort retrospective unexposed (general population or NOS) Adjustment: No 2.45 [1.62;3.71] 15/45   114,314/841,183 114,329 45
ref
S2387
R2952		 Paulus, 2013 Spontaneous abortion 1st trimester prospective cohort unexposed (general population or NOS) Adjustment: No 1.12 [0.39;3.21] C 5/57   15/189 20 57
ref
Total 4 studies 1.47 [0.82;2.63] 158,485 593
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Ishikawa, 2024Ishikawa, 2024 1.00[0.78; 1.27]44,11840534%ROB confusion: moderateROB selection: moderateROB classification: criticalROB missing: criticalROB mesure: criticalROB reporting: moderate Bellet, 2015Bellet, 2015 1.66[0.63; 4.38]188618%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: moderateROB mesure: unclearROB reporting: moderate Sorensen, 2015Sorensen, 2015 2.45[1.62; 3.71]114,3294531%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Paulus, 2013Paulus, 2013 1.12[0.39; 3.21]205717%ROB confusion: criticalROB selection: unclearROB classification: moderateROB missing: unclearROB mesure: unclearROB reporting: unclear Total (4 studies) I2 = 78% 1.47[0.82; 2.63]158,4855930.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.08[1.41; 3.07]114,3671886%NABellet, 2015 Sorensen, 2015 Paulus, 2013 3 case control studiescase control studies 1.00[0.78; 1.28]44,118405 -NAIshikawa, 2024 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.47[0.82; 2.63]158,48559378%NAIshikawa, 2024 Bellet, 2015 Sorensen, 2015 Paulus, 2013 4 Tags Adjustment   - No  - No 2.08[1.41; 3.07]114,3671886%NABellet, 2015 Sorensen, 2015 Paulus, 2013 3   - Yes  - Yes 1.00[0.78; 1.28]44,118405 -NAIshikawa, 2024 1 All studiesAll studies 1.47[0.82; 2.63]158,48559378%NAIshikawa, 2024 Bellet, 2015 Sorensen, 2015 Paulus, 2013 40.55.01.0

Publication bias and p-hacking diagnosis

funnel plot
0.0-1.31.70.6480.000Ishikawa, 2024Bellet, 2015Sorensen, 2015Paulus, 2013

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot
0.01.00.01.0

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.47[0.82; 2.63]158,48559378%NAIshikawa, 2024 Bellet, 2015 Sorensen, 2015 Paulus, 2013 40.510.01.0