Clozapine updated on 06-10-2025

Intrauterine deaths (as a whole or unspecified)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18337
R77360		 Kulkarni, 2024 Miscarriage / stillbirth at least 1st trimester prospective cohort unexposed, sick Adjustment: No 15.67 [0.74;331.22] C 3/14   0/24 3 14
ref
Total 1 studies 15.67 [0.74;331.22] 3 14
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Kulkarni, 2024Kulkarni, 2024 15.67[0.74; 331.22]3140%ROB confusion: criticalROB selection: lowROB classification: lowROB missing: lowROB mesure: moderateROB reporting: low0.950.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 15.67[0.74; 331.22]314 -NAKulkarni, 2024 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 15.67[0.74; 331.22]314 -NAKulkarni, 2024 1 Tags Adjustment   - No  - No 15.67[0.74; 331.22]314 -NAKulkarni, 2024 1 All studiesAll studies 15.67[0.74; 331.22]314 -NAKulkarni, 2024 10.550.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls Out of scale15.67[0.74; 331.22]314 -NAKulkarni, 2024 10.510.01.0