Olanzapine updated on 06-10-2025

Gestational diabetes

R analysis
id Study   Lib. in paper Exposition period    Study type  Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S14440
R57298
Wang - HK cohort, 2021 Gestational diabetes mellitus (GDM; using ICD code or a clinician reported GDM) during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed, sick Adjustment: Yes 0.82 [0.28;2.45] -/-   40/340 - -
ref
S14441
R57299
Wang - UK cohort, 2021 Gestational diabetes mellitus (GDM; using Read Code classification or a recorded fasting plasma glucose level of 5.6 mmol/l or above or a 2-h plasma glucose level of 7.8 mmol/l or above) during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed, sick Adjustment: Yes 1.53 [0.33;6.95] -/-   40/1,577 - -
ref
S3192
R5109
Park, 2018 Gestational diabetes at least 1st trimester retrospective cohort (claims database) unexposed, sick Adjustment: Yes 1.61 [1.13;2.29] 46/384   49/1,041 95 384
ref
S2457
R3134
Vigod, 2015 Gestational diabetes during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed, sick Adjustment: No 1.31 [0.71;2.45] C 13/166   62/1,021 75 166
ref
S3850
R8189
Boden (Control exposed to other antipsyhcotics), 2012 Gestational diabetes during pregnancy (anytime or not specified) population based cohort retrospective exposed to other treatment, sick excluded Adjustment: No 0.93 [0.37;2.33] C
excluded (control group)
7/169   15/338 22 169
ref
S2408
R3075
Boden (Control unexposed, NOS), 2012 Gestational diabetes during pregnancy (anytime or not specified) population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes 1.94 [0.97;3.91] 7/169   5,970/357,696 5,977 169
ref
Total 5 studies 1.53 [1.17;2.00] 6,147 719
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Wang - HK cohort, 2021Wang - HK cohort, 2021 0.82[0.28; 2.45]--6%ROB confusion: seriousROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Wang - UK cohort, 2021Wang - UK cohort, 2021 1.53[0.33; 6.95]--3%ROB confusion: moderateROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Park, 2018Park, 2018 1.61[1.13; 2.29]9538457%ROB confusion: moderateROB selection: lowROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Vigod, 2015Vigod, 2015 1.31[0.71; 2.45]7516619%ROB confusion: unclearROB selection: lowROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Boden (Control unexposed, NOS), 2012Boden, 2012 1 1.94[0.97; 3.91]5,97716915%ROB confusion: seriousROB selection: lowROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Total (5 studies) I2 = 0% 1.53[1.17; 2.00]6,1477190.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Control unexposed, NOS;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.53[1.17; 2.00]6,1477190%NAWang - HK cohort, 2021 Wang - UK cohort, 2021 Park, 2018 Vigod, 2015 Boden (Control unexposed, NOS), 2012 5 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.94[0.97; 3.89]5,977169 -NABoden (Control unexposed, NOS), 2012 1 unexposed, sickunexposed, sick 1.47[1.10; 1.96]1705500%NAWang - HK cohort, 2021 Wang - UK cohort, 2021 Park, 2018 Vigod, 2015 4 Tags Adjustment   - No  - No 1.31[0.71; 2.45]75166 -NAVigod, 2015 1   - Yes  - Yes 1.58[1.17; 2.13]6,0725530%NAWang - HK cohort, 2021 Wang - UK cohort, 2021 Park, 2018 Boden (Control unexposed, NOS), 2012 4 All studiesAll studies 1.53[1.17; 2.00]6,1477190%NAWang - HK cohort, 2021 Wang - UK cohort, 2021 Park, 2018 Vigod, 2015 Boden (Control unexposed, NOS), 2012 50.25.01.0

Publication bias and p-hacking diagnosis

funnel plot
0.0-1.82.30.9330.000Wang - HK cohort, 2021Wang - UK cohort, 2021Park, 2018Vigod, 2015Boden (Control unexposed, NOS), 2012

Asymetry test p-value = 0.4607 (by Egger's regression)

slope=0.5920 (0.2239); intercept=-0.6184 (0.7327); t=0.8439; p=0.4607

p values plot
0.01.00.01.0

Sub-groups analysis using all included studies

excluded 3850

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.94[0.97; 3.89]5,977169 -NABoden (Control unexposed, NOS), 2012 1 unexposed, sick controlsunexposed, sick controls 1.47[1.10; 1.96]2325500%NAWang - HK cohort, 2021 Wang - UK cohort, 2021 Park, 2018 Vigod, 2015 4 exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.93[0.37; 2.33]22169 -NABoden (Control exposed to other antipsyhcotics), 2012 10.510.01.0