Olanzapine updated on 06-10-2025

Ano-rectal atresia and stenosis

R analysis
id Study   Lib. in paper Exposition period    Study type  Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S14305
R56422
Huybrechts (Controls unexposed, NOS), 2023 Anorectal Atresia/Stenosis 1st trimester population based cohort retrospective unexposed (general population or NOS) excluded Adjustment: Yes 2.01 [0.65;6.22]
excluded (control group)
-/3,110   -/6,455,324 - 3,110
ref
S14304
R56410
Huybrechts (Controls unexposed, sick), 2023 Anorectal Atresia/Stenosis 1st trimester population based cohort retrospective unexposed, sick Adjustment: Yes 2.49 [0.80;7.74] -/2,341   -/318,731 - 2,341
ref
S2480
R3276
Raguideau, 2017 Ano-rectal atresia early pregnancy retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: No 2.13 [0.13;34.20] C 0/770   574/1,888,130 574 770
ref
Total 2 studies 2.44 [0.85;6.96] 574 3,111
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Huybrechts (Controls unexposed, sick), 2023Huybrechts, 2023 1 2.49[0.80; 7.74]-2,34186%ROB confusion: moderateROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: unclearROB reporting: moderate Raguideau, 2017Raguideau, 2017 2.13[0.13; 34.20]57477014%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 0% 2.44[0.85; 6.96]5743,1110.95.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.44[0.85; 6.96]5743,1110%NAHuybrechts (Controls unexposed, sick), 2023 Raguideau, 2017 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 2.13[0.13; 34.20]574770 -NARaguideau, 2017 1 unexposed, sickunexposed, sick 2.49[0.80; 7.75]-2,341 -NAHuybrechts (Controls unexposed, sick), 2023 1 Tags Adjustment   - No  - No 2.13[0.13; 34.20]574770 -NARaguideau, 2017 1   - Yes  - Yes 2.49[0.80; 7.75]-2,341 -NAHuybrechts (Controls unexposed, sick), 2023 1 All studiesAll studies 2.44[0.85; 6.96]5743,1110%NAHuybrechts (Controls unexposed, sick), 2023 Raguideau, 2017 20.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 14305

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 2.03[0.71; 5.77]5743,8800%NAHuybrechts (Controls unexposed, NOS), 2023 Raguideau, 2017 2 unexposed, sick controlsunexposed, sick controls 2.49[0.80; 7.75]-2,341 -NAHuybrechts (Controls unexposed, sick), 2023 10.510.01.0