Olanzapine updated on 06-10-2025

Microcephaly / Small head circumference for gestational age

R analysis
id Study   Lib. in paper Exposition period    Study type  Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S2480
R3262
Raguideau, 2017 Microcephaly (ICD10-Q02 and brain MRI, assessed until 24 months of age) early pregnancy retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: No 2.58 [0.16;41.43] C 0/770   474/1,888,130 474 770
ref
S3850
R8185
Boden (Control exposed to other antipsyhcotics), 2012 Small for gestational age (head circumference < 2.3rd percentile) during pregnancy (anytime or not specified) population based cohort retrospective exposed to other treatment, sick excluded Adjustment: No 0.42 [0.14;1.26] C
excluded (control group)
4/186   17/340 21 186
ref
S2408
R3070
Boden (Control unexposed, NOS), 2012 Small for gestational age (head circumference < 2.3rd percentile) during pregnancy (anytime or not specified) population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes 0.62 [0.19;2.01] 4/186   -/- - 186
ref
Total 2 studies 0.77 [0.26;2.28] 474 956
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Raguideau, 2017Raguideau, 2017 2.58[0.16; 41.43]47477015%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate Boden (Control unexposed, NOS), 2012Boden, 2012 1 0.62[0.19; 2.01]-18685%ROB confusion: seriousROB selection: lowROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 0% 0.77[0.26; 2.28]4749560.210.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Control unexposed, NOS;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.77[0.26; 2.28]4749560%NARaguideau, 2017 Boden (Control unexposed, NOS), 2012 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.77[0.26; 2.28]4749560%NARaguideau, 2017 Boden (Control unexposed, NOS), 2012 2 Tags Adjustment   - No  - No 2.58[0.16; 41.43]474770 -NARaguideau, 2017 1   - Yes  - Yes 0.62[0.19; 2.02]-186 -NABoden (Control unexposed, NOS), 2012 1 All studiesAll studies 0.77[0.26; 2.28]4749560%NARaguideau, 2017 Boden (Control unexposed, NOS), 2012 20.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3850

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.77[0.26; 2.28]4749560%NARaguideau, 2017 Boden (Control unexposed, NOS), 2012 2 exposed to other treatment, sick controlsexposed to other treatment, sick controls Out of scale0.42[0.14; 1.26]21186 -NABoden (Control exposed to other antipsyhcotics), 2012 10.510.01.0