Olanzapine updated on 06-10-2025

Psychomotor developmental disorders/delay

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S12477
R46968		 Straub, 2022 Developmental Coordination Disorder (≥ 2 dates with ICD-9 Dx 315.4) - By 8 years of age 2nd and/or 3rd trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes 0.89 [0.40;2.01] -/1,327   8,230/2,002,687 - 1,327
ref
Total 1 studies 0.89 [0.40;2.00] 0 1,327
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Straub, 2022Straub, 2022 0.89[0.40; 2.01]-1,3270%ROB confusion: moderateROB selection: lowROB classification: criticalROB missing: unclearROB mesure: criticalROB reporting: moderate0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.89[0.40; 2.00]-1,327 -NAStraub, 2022 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.89[0.40; 2.00]-1,327 -NAStraub, 2022 1 Tags Adjustment   - Yes  - Yes 0.89[0.40; 2.00]-1,327 -NAStraub, 2022 1 All studiesAll studies 0.89[0.40; 2.00]-1,327 -NAStraub, 2022 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.89[0.40; 2.00]8,2211,327 -NAStraub, 2022 10.510.01.0