id | Study | Lib. in paper | Exposition period | Study type |
Control type |
Tags | OR 95%CI | x1/n1 x0/n0 | no cases | no exposed | ROB | Ref. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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S18397 R77621 |
Chan (Controls exposed to FGA), 2024 | Major congenital malformations | at least 1st trimester | retrospective cohort (claims database) | exposed to other treatment, sick excluded | Adjustment: No |
1.19 [0.52;2.70] C excluded (control group) |
8/110 26/420 | 34 | 110 |
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ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S18340 R77622 |
Chan (Controls unexposed, general pop), 2024 | Major congenital malformations | at least 1st trimester | retrospective cohort (claims database) | unexposed (general population or NOS) excluded | Adjustment: Yes |
0.65 [0.22;1.73] excluded (control group) |
8/110 22,929/464,017 | 22,937 | 110 |
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ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S18394 R77623 |
Chan (Controls unexposed, sick), 2024 | Major congenital malformations | at least 1st trimester | retrospective cohort (claims database) | unexposed, sick | Adjustment: Yes | 1.71 [0.44;8.36] | 7/101 385/6,476 | 392 | 101 |
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ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S14305 R56427 |
Huybrechts (Controls unexposed, NOS), 2023 | Major congenital malformations overall (excluding chromosomal abnormality) | 1st trimester | population based cohort retrospective | unexposed (general population or NOS) excluded | Adjustment: Yes |
1.20 [1.01;1.42] excluded (control group) |
137/3,110 177,165/6,455,324 | 177,302 | 3,110 |
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ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S14304 R56415 |
Huybrechts (Controls unexposed, sick), 2023 | Major congenital malformations overall (excluding chromosomal abnormality) | 1st trimester | population based cohort retrospective | unexposed, sick | Adjustment: Yes | 1.18 [0.97;1.42] | 106/2,341 11,647/318,731 | 11,753 | 2,341 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S14432 R77643 |
Viguera, 2023 | Major congenital malformations | 1st trimester | prospective cohort | unexposed, sick | Adjustment: No | 0.60 [0.04;10.10] C | 0/49 19/1,156 | 19 | 49 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S2480 R11434 |
Raguideau, 2017 | 26 major malformations | early pregnancy | retrospective cohort (claims database) | unexposed (general population or NOS) | Adjustment: Yes | 1.10 [0.60;2.20] | 9/770 18,682/1,888,130 | 18,691 | 770 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S3896 R11432 |
Ozturk, 2016 | Major birth defects | during pregnancy (anytime or not specified) excluded | retrospective cohort | unexposed (general population or NOS) | Adjustment: No |
7.70 [0.34;172.00] C excluded (exposition period) |
0/5 3/246 | 3 | 5 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S2477 R11430 |
Källen, 2013 | Relatively severe malformations | early pregnancy | population based cohort retrospective | unexposed (general population or NOS) | Adjustment: No | 0.93 [0.40;1.84] | 6/205 -/- | - | 205 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S2701 R11433 |
Peng, 2013 | Major malformations | throughout pregnancy | prospective cohort | unexposed, disease free | Adjustment: No | 10.07 [0.19;544.79] C | 0/8 0/76 | 0 | 8 |
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ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S2696 R11437 |
Sadowski, 2013 | Major malformations | during pregnancy (anytime or not specified) excluded | prospective cohort | unexposed, disease free | Adjustment: No |
1.71 [0.17;17.23] C excluded (exposition period) |
1/23 3/116 | 4 | 23 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S2703 R11431 |
McKenna, 2005 | Major malformations | 1st trimester | prospective cohort | unexposed, disease free | Adjustment: No | 1.13 [0.10;12.68] C | 1/60 2/135 | 3 | 60 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Total | 7 studies | 1.17 [0.98;1.39] | 30,858 | 3,534 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives |
1: Controls unexposed, sick; 2: Controls unexposed, sick;
Asymetry test p-value = 0.7438 (by Egger's regression)
slope=0.1379 (0.0732); intercept=0.1068 (0.3090); t=0.3454; p=0.7438
excluded 14305, 18397, 18340