Olanzapine updated on 06-10-2025

Preterm (< 37 weeks)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3896
R8259		 Ozturk, 2016 Preterm birth (<37 weeks) during pregnancy (anytime or not specified) retrospective cohort unexposed (general population or NOS) Adjustment: No 3.10 [0.15;62.41] C 0/5   8/246 8 5
ref
S2457
R3137		 Vigod, 2015 Preterm birth <37 weeks gestation during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed, sick Adjustment: No 0.92 [0.57;1.48] C 22/166   146/1,021 168 166
ref
S3850
R8190		 Boden (Control exposed to other antipsyhcotics), 2012 Preterm (before 37 weeks of gestation) during pregnancy (anytime or not specified) population based cohort retrospective exposed to other treatment, sick excluded Adjustment: No 0.86 [0.45;1.67] C
excluded (control group) 		14/169   32/338 46 169
ref
S2408
R3076		 Boden (Control unexposed, NOS), 2012 Preterm (before 37 weeks of gestation) during pregnancy (anytime or not specified) population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes 1.58 [0.91;2.73] 14/169   -/- - 169
ref
S2473
R3198		 Newport, 2007 Preterm (<37 weeks estimated gestational age) late pregnancy prospective cohort exposed to other treatment, sick Adjustment: No 8.33 [0.39;180.37] C 3/14   0/13 3 14
ref
Total 4 studies 1.28 [0.77;2.11] 179 354
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Ozturk, 2016Ozturk, 2016 3.10[0.15; 62.41]853%ROB confusion: criticalROB selection: unclearROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Vigod, 2015Vigod, 2015 0.92[0.57; 1.48]16816650%ROB confusion: unclearROB selection: lowROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Boden (Control unexposed, NOS), 2012Boden, 2012 1 1.58[0.91; 2.73]-16944%ROB confusion: seriousROB selection: lowROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Newport, 2007Newport, 2007 8.33[0.39; 180.37]3143%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (4 studies) I2 = 27% 1.28[0.77; 2.11]1793540.220.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Control unexposed, NOS;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.28[0.77; 2.11]17935427%NAOzturk, 2016 Vigod, 2015 Boden (Control unexposed, NOS), 2012 Newport, 2007 4 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.61[0.94; 2.77]81740%NAOzturk, 2016 Boden (Control unexposed, NOS), 2012 2 unexposed, sickunexposed, sick 0.92[0.57; 1.48]168166 -NAVigod, 2015 1 exposed to other treatment, sickexposed to other treatment, sick 8.33[0.39; 180.37]314 -NANewport, 2007 1 Tags Adjustment   - No  - No 1.32[0.46; 3.82]17918520%NAOzturk, 2016 Vigod, 2015 Newport, 2007 3   - Yes  - Yes 1.58[0.91; 2.74]-169 -NABoden (Control unexposed, NOS), 2012 1 All studiesAll studies 1.28[0.77; 2.11]17935427%NAOzturk, 2016 Vigod, 2015 Boden (Control unexposed, NOS), 2012 Newport, 2007 40.220.01.0

Publication bias and p-hacking diagnosis

funnel plot
0.0-3.73.91.8820.000Ozturk, 2016Vigod, 2015Boden (Control unexposed, NOS), 2012Newport, 2007

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot
0.01.00.01.0

Sub-groups analysis using all included studies

excluded 3850

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.61[0.94; 2.77]131740%NAOzturk, 2016 Boden (Control unexposed, NOS), 2012 2 unexposed, sick controlsunexposed, sick controls 0.92[0.57; 1.48]168166 -NAVigod, 2015 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.60[0.22; 11.53]4918350%NABoden (Control exposed to other antipsyhcotics), 2012 Newport, 2007 20.510.01.0