Olanzapine updated on 06-10-2025

Small for gestational age (weight)

R analysis
id Study   Lib. in paper Exposition period    Study type  Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S2457
R3138
Vigod, 2015 Small for gestational age (birth weight < 3rd centile) during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed, sick Adjustment: No 1.62 [0.86;3.04] C 13/166   51/1,021 64 166
ref
S3850
R8183
Boden (Control exposed to other antipsyhcotics), 2012 Small for gestational age (birth weight < 2.3rd percentile) during pregnancy (anytime or not specified) population based cohort retrospective exposed to other treatment, sick excluded Adjustment: No 1.12 [0.50;2.50] C
excluded (control group)
10/187   17/354 27 187
ref
S2408
R3068
Boden (Control unexposed, NOS), 2012 Small for gestational age (birth weight < 2.3rd percentile) during pregnancy (anytime or not specified) population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes 1.82 [0.91;3.61] 10/187   -/- - 187
ref
Total 2 studies 1.71 [1.07;2.72] 64 353
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Vigod, 2015Vigod, 2015 1.62[0.86; 3.04]6416654%ROB confusion: unclearROB selection: lowROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Boden (Control unexposed, NOS), 2012Boden, 2012 1 1.82[0.91; 3.61]-18746%ROB confusion: seriousROB selection: lowROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 0% 1.71[1.07; 2.72]643530.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Control unexposed, NOS;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.71[1.07; 2.72]643530%NAVigod, 2015 Boden (Control unexposed, NOS), 2012 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.82[0.91; 3.62]-187 -NABoden (Control unexposed, NOS), 2012 1 unexposed, sickunexposed, sick 1.62[0.86; 3.04]64166 -NAVigod, 2015 1 Tags Adjustment   - No  - No 1.62[0.86; 3.04]64166 -NAVigod, 2015 1   - Yes  - Yes 1.82[0.91; 3.62]-187 -NABoden (Control unexposed, NOS), 2012 1 All studiesAll studies 1.71[1.07; 2.72]643530%NAVigod, 2015 Boden (Control unexposed, NOS), 2012 20.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3850

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.82[0.91; 3.62]1187 -NABoden (Control unexposed, NOS), 2012 1 unexposed, sick controlsunexposed, sick controls 1.62[0.86; 3.04]64166 -NAVigod, 2015 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.12[0.50; 2.50]27187 -NABoden (Control exposed to other antipsyhcotics), 2012 10.510.01.0