Quetiapine updated on 06-10-2025

Neonatal medical care

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18404
R77671		 Kulkarni, 2024 Neonatal Intensive Care Unit or Special Care Nursery admission at least 1st trimester excluded prospective cohort unexposed, sick Adjustment: No 1.30 [0.46;3.62] C
excluded (exposition period) 		20/44   9/23 29 44
ref
S18403
R77661		 Kananen, 2023 Admission to neonatal intensive care unit (NICU) during pregnancy (anytime or not specified) retrospective cohort unexposed (general population or NOS) Adjustment: Yes 1.13 [0.78;1.63] 45/152   5,464/35,133 5,509 152
ref
S2474
R3209		 Newport, 2007 Neonatal intensive care unit admission late pregnancy prospective cohort exposed to other treatment, sick Adjustment: No 3.38 [0.15;76.51] C 2/21   0/13 2 21
ref
Total 2 studies 1.15 [0.80;1.65] 5,511 173
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Kananen, 2023Kananen, 2023 1.13[0.78; 1.63]5,50915299%ROB confusion: seriousROB selection: unclearROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Newport, 2007Newport, 2007 3.38[0.15; 76.51]2211%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 0% 1.15[0.80; 1.65]5,5111730.510.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.15[0.80; 1.65]5,5111730%NAKananen, 2023 Newport, 2007 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.13[0.78; 1.63]5,509152 -NAKananen, 2023 1 exposed to other treatment, sickexposed to other treatment, sick 3.38[0.15; 76.51]221 -NANewport, 2007 1 Tags Adjustment   - No  - No 3.38[0.15; 76.51]221 -NANewport, 2007 1   - Yes  - Yes 1.13[0.78; 1.63]5,509152 -NAKananen, 2023 1 All studiesAll studies 1.15[0.80; 1.65]5,5111730%NAKananen, 2023 Newport, 2007 20.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.13[0.78; 1.63]5,509152 -NAKananen, 2023 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 3.38[0.15; 76.51]221 -NANewport, 2007 10.510.01.0