Quetiapine updated on 06-10-2025

Gestational diabetes

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18404
R77669		 Kulkarni, 2024 Gestational diabetes mellitus at least 1st trimester prospective cohort unexposed, sick Adjustment: No 3.46 [0.70;17.09] C 11/46   2/24 13 46
ref
S14436
R57294		 Wang - HK cohort, 2021 Gestational diabetes mellitus (GDM; using ICD code or a clinician reported GDM) during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed, sick Adjustment: Yes 1.49 [0.57;3.85] 8/-   40/340 48 -
ref
S14437
R57295		 Wang - UK cohort, 2021 Gestational diabetes mellitus (GDM; using Read Code classification or a recorded fasting plasma glucose level of 5.6 mmol/l or above or a 2-h plasma glucose level of 7.8 mmol/l or above) during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed, sick Adjustment: Yes 2.12 [0.38;16.66] 7/-   40/1,577 47 -
ref
S3189
R5106		 Park, 2018 Gestational diabetes at least 1st trimester retrospective cohort (claims database) unexposed, sick Adjustment: Yes 1.28 [1.01;1.62] 110/1,543   122/2,990 232 1,543
ref
S2456
R3120		 Vigod, 2015 Gestational diabetes during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed, sick Adjustment: No 1.20 [0.79;1.81] C 40/556   62/1,021 102 556
ref
Total 5 studies 1.30 [1.06;1.58] 442 2,145
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Kulkarni, 2024Kulkarni, 2024 3.46[0.70; 17.09]13462%ROB confusion: criticalROB selection: lowROB classification: lowROB missing: lowROB mesure: moderateROB reporting: low Wang - HK cohort, 2021Wang - HK cohort, 2021 1.49[0.57; 3.85]48-4%ROB confusion: seriousROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Wang - UK cohort, 2021Wang - UK cohort, 2021 2.12[0.38; 16.66]47-1%ROB confusion: moderateROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Park, 2018Park, 2018 1.28[1.01; 1.62]2321,54370%ROB confusion: moderateROB selection: lowROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Vigod, 2015Vigod, 2015 1.20[0.79; 1.81]10255623%ROB confusion: unclearROB selection: lowROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Total (5 studies) I2 = 0% 1.30[1.06; 1.58]4422,1450.510.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.30[1.06; 1.58]4422,1450%NAKulkarni, 2024 Wang - HK cohort, 2021 Wang - UK cohort, 2021 Park, 2018 Vigod, 2015 5 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.30[1.06; 1.58]4422,1450%NAKulkarni, 2024 Wang - HK cohort, 2021 Wang - UK cohort, 2021 Park, 2018 Vigod, 2015 5 Tags Adjustment   - No  - No 1.52[0.64; 3.60]11560237%NAKulkarni, 2024 Vigod, 2015 2   - Yes  - Yes 1.30[1.04; 1.63]3271,5430%NAWang - HK cohort, 2021 Wang - UK cohort, 2021 Park, 2018 3 All studiesAll studies 1.30[1.06; 1.58]4422,1450%NAKulkarni, 2024 Wang - HK cohort, 2021 Wang - UK cohort, 2021 Park, 2018 Vigod, 2015 50.510.01.0

Publication bias and p-hacking diagnosis

funnel plot
0.0-2.32.51.1570.000Kulkarni, 2024Wang - HK cohort, 2021Wang - UK cohort, 2021Park, 2018Vigod, 2015

Asymetry test p-value = 0.1104 (by Egger's regression)

slope=0.1188 (0.0797); intercept=0.7936 (0.3534); t=2.2456; p=0.1104

p values plot
0.01.00.01.0

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 1.30[1.06; 1.58]4422,1450%NAKulkarni, 2024 Wang - HK cohort, 2021 Wang - UK cohort, 2021 Park, 2018 Vigod, 2015 50.510.01.0