Quetiapine updated on 06-10-2025

Neonatal death (< 28 days of life)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18403
R77665		 Kananen, 2023 Died during the first neonatal week during pregnancy (anytime or not specified) retrospective cohort unexposed (general population or NOS) Adjustment: No 3.93 [0.24;64.57] C 0/152   29/35,133 29 152
ref
S2478
R3227		 Källen, 2013 Neonatal morbidity (NOS) 2nd and/or 3rd trimester population based cohort retrospective unexposed (general population or NOS) Adjustment: No 1.98 [1.04;1.98] -/57   -/- - 57
ref
Total 2 studies 2.00 [1.45;2.75] 29 209
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Kananen, 2023Kananen, 2023 3.93[0.24; 64.57]291521%ROB confusion: criticalROB selection: unclearROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Källen, 2013Källen, 2013 1.98[1.04; 1.98]-5799%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 0% 2.00[1.45; 2.75]292090.510.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.00[1.45; 2.75]292090%NAKananen, 2023 Källen, 2013 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 2.00[1.45; 2.75]292090%NAKananen, 2023 Källen, 2013 2 Tags Adjustment   - No  - No 2.00[1.45; 2.75]292090%NAKananen, 2023 Källen, 2013 2 All studiesAll studies 2.00[1.45; 2.75]292090%NAKananen, 2023 Källen, 2013 20.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 2.00[1.45; 2.75]292090%NAKananen, 2023 Källen, 2013 20.510.01.0