Quetiapine updated on 06-10-2025

Limb reduction defects (LRD)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S14301
R56373		 Huybrechts (Controls unexposed, NOS), 2023 Limb reduction Defect 1st trimester population based cohort retrospective unexposed (general population or NOS) excluded Adjustment: Yes 0.53 [0.13;2.14]
excluded (control group) 		-/11,065   -/6,455,324 - 11,065
ref
S14300
R56361		 Huybrechts (Controls unexposed, sick), 2023 Limb reduction Defect 1st trimester population based cohort retrospective unexposed, sick Adjustment: Yes 0.88 [0.22;3.51] -/8,350   -/318,731 - 8,350
ref
Total 1 studies 0.88 [0.22;3.51] 0 8,350
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Huybrechts (Controls unexposed, sick), 2023Huybrechts, 2023 1 0.88[0.22; 3.51]-8,3500%ROB confusion: moderateROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: unclearROB reporting: moderate0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.88[0.22; 3.51]-8,350 -NAHuybrechts (Controls unexposed, sick), 2023 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 0.88[0.22; 3.51]-8,350 -NAHuybrechts (Controls unexposed, sick), 2023 1 Tags Adjustment   - Yes  - Yes 0.88[0.22; 3.51]-8,350 -NAHuybrechts (Controls unexposed, sick), 2023 1 All studiesAll studies 0.88[0.22; 3.51]-8,350 -NAHuybrechts (Controls unexposed, sick), 2023 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 14301

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.53[0.13; 2.15]-11,065 -NAHuybrechts (Controls unexposed, NOS), 2023 1 unexposed, sick controlsunexposed, sick controls 0.88[0.22; 3.51]-8,350 -NAHuybrechts (Controls unexposed, sick), 2023 10.510.01.0