Quetiapine updated on 06-10-2025

Ano-rectal atresia and stenosis

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S14301
R56374		 Huybrechts (Controls unexposed, NOS), 2023 Anorectal Atresia/Stenosis 1st trimester population based cohort retrospective unexposed (general population or NOS) excluded Adjustment: Yes 0.97 [0.40;2.32]
excluded (control group) 		-/11,065   -/6,455,324 - 11,065
ref
S14300
R56362		 Huybrechts (Controls unexposed, sick), 2023 Anorectal Atresia/Stenosis 1st trimester population based cohort retrospective unexposed, sick Adjustment: Yes 0.97 [0.36;2.59] -/8,350   -/318,731 - 8,350
ref
S2482
R3330		 Raguideau, 2017 Ano-rectal atresia early pregnancy retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: No 7.52 [0.47;120.73] C 0/219   574/1,888,130 574 219
ref
Total 2 studies 1.76 [0.28;10.90] 574 8,569
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Huybrechts (Controls unexposed, sick), 2023Huybrechts, 2023 1 0.97[0.36; 2.59]-8,35071%ROB confusion: moderateROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: unclearROB reporting: moderate Raguideau, 2017Raguideau, 2017 7.52[0.47; 120.73]57421929%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 46% 1.76[0.28; 10.90]5748,5690.220.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.76[0.28; 10.90]5748,56946%NAHuybrechts (Controls unexposed, sick), 2023 Raguideau, 2017 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 7.52[0.47; 120.73]574219 -NARaguideau, 2017 1 unexposed, sickunexposed, sick 0.97[0.36; 2.60]-8,350 -NAHuybrechts (Controls unexposed, sick), 2023 1 Tags Adjustment   - No  - No 7.52[0.47; 120.73]574219 -NARaguideau, 2017 1   - Yes  - Yes 0.97[0.36; 2.60]-8,350 -NAHuybrechts (Controls unexposed, sick), 2023 1 All studiesAll studies 1.76[0.28; 10.90]5748,56946%NAHuybrechts (Controls unexposed, sick), 2023 Raguideau, 2017 20.220.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 14301

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.74[0.28; 10.63]57411,28447%NAHuybrechts (Controls unexposed, NOS), 2023 Raguideau, 2017 2 unexposed, sick controlsunexposed, sick controls 0.97[0.36; 2.60]-8,350 -NAHuybrechts (Controls unexposed, sick), 2023 10.510.01.0