Quetiapine updated on 06-10-2025

Oesophageal atresia with or without tracheo-oesophageal fistula

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S14301
R56378		 Huybrechts (Controls unexposed, NOS), 2023 Esophageal Disorder 1st trimester population based cohort retrospective unexposed (general population or NOS) excluded Adjustment: Yes 0.32 [0.04;2.26]
excluded (control group) 		-/11,065   -/6,455,324 - 11,065
ref
S14300
R56366		 Huybrechts (Controls unexposed, sick), 2023 Esophageal Disorder 1st trimester population based cohort retrospective unexposed, sick Adjustment: Yes 0.43 [0.06;3.05] -/8,350   -/318,731 - 8,350
ref
S2482
R3329		 Raguideau, 2017 Oesophageal atresia early pregnancy retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: No 10.32 [0.64;165.83] C 0/219   418/1,888,130 418 219
ref
Total 2 studies 1.80 [0.08;39.91] 418 8,569
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Huybrechts (Controls unexposed, sick), 2023Huybrechts, 2023 1 0.43[0.06; 3.05]-8,35055%ROB confusion: moderateROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: unclearROB reporting: moderate Raguideau, 2017Raguideau, 2017 10.32[0.64; 165.83]41821945%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 70% 1.80[0.08; 39.91]4188,5690.250.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.80[0.08; 39.91]4188,56970%NAHuybrechts (Controls unexposed, sick), 2023 Raguideau, 2017 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 10.32[0.64; 165.83]418219 -NARaguideau, 2017 1 unexposed, sickunexposed, sick 0.43[0.06; 3.07]-8,350 -NAHuybrechts (Controls unexposed, sick), 2023 1 Tags Adjustment   - No  - No 10.32[0.64; 165.83]418219 -NARaguideau, 2017 1   - Yes  - Yes 0.43[0.06; 3.07]-8,350 -NAHuybrechts (Controls unexposed, sick), 2023 1 All studiesAll studies 1.80[0.08; 39.91]4188,56970%NAHuybrechts (Controls unexposed, sick), 2023 Raguideau, 2017 20.250.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 14301

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.59[0.05; 47.21]41811,28475%NAHuybrechts (Controls unexposed, NOS), 2023 Raguideau, 2017 2 unexposed, sick controlsunexposed, sick controls Out of scale0.43[0.06; 3.07]-8,350 -NAHuybrechts (Controls unexposed, sick), 2023 10.510.01.0