Quetiapine updated on 06-10-2025

Gastroschisis

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S14301
R56375		 Huybrechts (Controls unexposed, NOS), 2023 Gastroschisis 1st trimester population based cohort retrospective unexposed (general population or NOS) excluded Adjustment: Yes 1.55 [0.70;3.45]
excluded (control group) 		-/11,065   -/6,455,324 - 11,065
ref
S14300
R56363		 Huybrechts (Controls unexposed, sick), 2023 Gastroschisis 1st trimester population based cohort retrospective unexposed, sick Adjustment: Yes 1.72 [0.71;4.12] -/8,350   -/318,731 - 8,350
ref
S2482
R3335		 Raguideau, 2017 Laparoschisis early pregnancy retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: No 17.53 [1.09;281.89] C 0/219   246/1,888,130 246 219
ref
Total 2 studies 3.72 [0.44;31.72] 246 8,569
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Huybrechts (Controls unexposed, sick), 2023Huybrechts, 2023 1 1.72[0.71; 4.12]-8,35067%ROB confusion: moderateROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: unclearROB reporting: moderate Raguideau, 2017Raguideau, 2017 17.53[1.09; 281.89]24621933%ROB confusion: criticalROB selection: lowROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 59% 3.72[0.44; 31.72]2468,5690.550.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 3.72[0.44; 31.72]2468,56959%NAHuybrechts (Controls unexposed, sick), 2023 Raguideau, 2017 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 17.53[1.09; 281.89]246219 -NARaguideau, 2017 1 unexposed, sickunexposed, sick 1.72[0.71; 4.14]-8,350 -NAHuybrechts (Controls unexposed, sick), 2023 1 Tags Adjustment   - No  - No 17.53[1.09; 281.89]246219 -NARaguideau, 2017 1   - Yes  - Yes 1.72[0.71; 4.14]-8,350 -NAHuybrechts (Controls unexposed, sick), 2023 1 All studiesAll studies 3.72[0.44; 31.72]2468,56959%NAHuybrechts (Controls unexposed, sick), 2023 Raguideau, 2017 20.550.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 14301

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 3.56[0.37; 34.06]24611,28463%NAHuybrechts (Controls unexposed, NOS), 2023 Raguideau, 2017 2 unexposed, sick controlsunexposed, sick controls 1.72[0.71; 4.14]-8,350 -NAHuybrechts (Controls unexposed, sick), 2023 10.510.01.0