Quetiapine updated on 06-10-2025

Microcephaly / Small head circumference for gestational age

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S2482
R3316		 Raguideau, 2017 Microcephaly (ICD10-Q02 and brain MRI, assessed until 24 months of age) early pregnancy retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: No 9.10 [0.57;146.22] C 0/219   474/1,888,130 474 219
ref
Total 1 studies 9.10 [0.57;146.22] 474 219
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Raguideau, 2017Raguideau, 2017 9.10[0.57; 146.22]4742190%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate0.920.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 9.10[0.57; 146.22]474219 -NARaguideau, 2017 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 9.10[0.57; 146.22]474219 -NARaguideau, 2017 1 Tags Adjustment   - No  - No 9.10[0.57; 146.22]474219 -NARaguideau, 2017 1 All studiesAll studies 9.10[0.57; 146.22]474219 -NARaguideau, 2017 10.520.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 9.10[0.57; 146.22]474219 -NARaguideau, 2017 10.510.01.0