Quetiapine updated on 06-10-2025

ASD (Autism spectrum disorder): Diagnosis/Risk

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S12475
R57275		 Straub, 2022 Autism spectrum disorder (ASD) (≥ 2 dates with ICD-9 Dx 299.xx) - By 8 years of age 2nd and/or 3rd trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes 1.12 [0.81;1.54] 45/4,457   13,429/3,309,095 13,474 4,457
ref
Total 1 studies 1.12 [0.81;1.54] 13,474 4,457
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Straub, 2022Straub, 2022 1.12[0.81; 1.54]13,4744,4570%ROB confusion: moderateROB selection: lowROB classification: criticalROB missing: unclearROB mesure: criticalROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.12[0.81; 1.54]13,4744,457 -NAStraub, 2022 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.12[0.81; 1.54]13,4744,457 -NAStraub, 2022 1 Tags Adjustment   - Yes  - Yes 1.12[0.81; 1.54]13,4744,457 -NAStraub, 2022 1 All studiesAll studies 1.12[0.81; 1.54]13,4744,457 -NAStraub, 2022 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.12[0.81; 1.54]13,4744,457 -NAStraub, 2022 10.510.01.0