Quetiapine updated on 06-10-2025

Cognitive developmental disorders/delay (> 6 years old)

R analysis
id Study   Lib. in paper Exposition period    Study type  Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18405
R77679
Bruno, 2024 Cognitive developmental disorders/delay (ICD-10 codes F70.0–F73.0) - Median follow-up: 6.7 years during pregnancy (anytime or not specified) population based cohort retrospective unexposed, sick Adjustment: Yes 0.72 [0.35;1.49] 10/3,894   869/197,296 879 3,894
ref
S12475
R77641
Straub, 2022 Intellectual disability (≥ 2 dates with ICD-9 Dx 317, 318.x, 319) - By 8 years of age 2nd and/or 3rd trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes 1.22 [0.59;2.54] -/3,927   3,348/2,002,687 - 3,927
ref
Total 2 studies 0.94 [0.56;1.57] 879 7,821
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Bruno, 2024Bruno, 2024 0.72[0.35; 1.49]8793,89450%ROB confusion: seriousROB selection: lowROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Straub, 2022Straub, 2022 1.22[0.59; 2.54]-3,92750%ROB confusion: moderateROB selection: lowROB classification: criticalROB missing: unclearROB mesure: criticalROB reporting: moderate Total (2 studies) I2 = 1% 0.94[0.56; 1.57]8797,8210.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.94[0.56; 1.57]8797,8211%NABruno, 2024 Straub, 2022 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.22[0.59; 2.53]-3,927 -NAStraub, 2022 1 unexposed, sickunexposed, sick 0.72[0.35; 1.49]8793,894 -NABruno, 2024 1 Tags Adjustment   - Yes  - Yes 0.94[0.56; 1.57]8797,8211%NABruno, 2024 Straub, 2022 2 All studiesAll studies 0.94[0.56; 1.57]8797,8211%NABruno, 2024 Straub, 2022 20.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.22[0.59; 2.53]3,3393,927 -NAStraub, 2022 1 unexposed, sick controlsunexposed, sick controls 0.72[0.35; 1.49]8793,894 -NABruno, 2024 10.510.01.0