Quetiapine updated on 06-10-2025

Congenital heart defects

R analysis
id Study   Lib. in paper Exposition period    Study type  Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18398
R77609
Chan (Controls exposed to FGA), 2024 Cardiac malformations at least 1st trimester retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: No 1.96 [0.70;5.48] C
excluded (control group)
7/191   8/420 15 191
ref
S18341
R77381
Chan (Controls unexposed, general pop), 2024 Cardiac malformations at least 1st trimester retrospective cohort (claims database) unexposed (general population or NOS) excluded Adjustment: Yes 1.28 [0.40;4.48]
excluded (control group)
7/191   8,218/464,017 8,225 191
ref
S18395
R77599
Chan (Controls unexposed, sick), 2024 Cardiac malformations at least 1st trimester retrospective cohort (claims database) unexposed, sick Adjustment: Yes 1.65 [0.48;6.66] 7/169   135/6,476 142 169
ref
S14301
R56369
Huybrechts (Controls unexposed, NOS), 2023 Cardiovascular Malformations 1st trimester population based cohort retrospective unexposed (general population or NOS) excluded Adjustment: Yes 1.08 [0.92;1.25]
excluded (control group)
-/11,065   -/6,455,324 - 11,065
ref
S14300
R56357
Huybrechts (Controls unexposed, sick), 2023 Cardiovascular Malformations 1st trimester population based cohort retrospective unexposed, sick Adjustment: Yes 1.08 [0.91;1.29] -/8,350   -/318,731 - 8,350
ref
Total 2 studies 1.09 [0.92;1.29] 142 8,519
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Chan (Controls unexposed, sick), 2024Chan, 2024 1 1.65[0.48; 6.66]1421692%ROB confusion: seriousROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Huybrechts (Controls unexposed, sick), 2023Huybrechts, 2023 2 1.08[0.91; 1.29]-8,35098%ROB confusion: moderateROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: unclearROB reporting: moderate Total (2 studies) I2 = 0% 1.09[0.92; 1.29]1428,5190.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick; 2: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.09[0.92; 1.29]1428,5190%NAChan (Controls unexposed, sick), 2024 Huybrechts (Controls unexposed, sick), 2023 2 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.09[0.92; 1.29]1428,5190%NAChan (Controls unexposed, sick), 2024 Huybrechts (Controls unexposed, sick), 2023 2 Tags Adjustment   - Yes  - Yes 1.09[0.92; 1.29]1428,5190%NAChan (Controls unexposed, sick), 2024 Huybrechts (Controls unexposed, sick), 2023 2 All studiesAll studies 1.09[0.92; 1.29]1428,5190%NAChan (Controls unexposed, sick), 2024 Huybrechts (Controls unexposed, sick), 2023 20.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 14301, 18398, 18341

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.08[0.93; 1.26]8,22511,2560%NAChan (Controls unexposed, general pop), 2024 Huybrechts (Controls unexposed, NOS), 2023 2 unexposed, sick controlsunexposed, sick controls 1.09[0.92; 1.29]1428,5190%NAChan (Controls unexposed, sick), 2024 Huybrechts (Controls unexposed, sick), 2023 2 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.96[0.70; 5.48]15191 -NAChan (Controls exposed to FGA), 2024 10.510.01.0