id | Study | Lib. in paper | Exposition period | Study type |
Control type |
Tags | OR 95%CI | x1/n1 x0/n0 | no cases | no exposed | ROB | Ref. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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S18398 R77609 |
Chan (Controls exposed to FGA), 2024 | Cardiac malformations | at least 1st trimester | retrospective cohort (claims database) | exposed to other treatment, sick excluded | Adjustment: No |
1.96 [0.70;5.48] C excluded (control group) |
7/191 8/420 | 15 | 191 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S18341 R77381 |
Chan (Controls unexposed, general pop), 2024 | Cardiac malformations | at least 1st trimester | retrospective cohort (claims database) | unexposed (general population or NOS) excluded | Adjustment: Yes |
1.28 [0.40;4.48] excluded (control group) |
7/191 8,218/464,017 | 8,225 | 191 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S18395 R77599 |
Chan (Controls unexposed, sick), 2024 | Cardiac malformations | at least 1st trimester | retrospective cohort (claims database) | unexposed, sick | Adjustment: Yes | 1.65 [0.48;6.66] | 7/169 135/6,476 | 142 | 169 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S14301 R56369 |
Huybrechts (Controls unexposed, NOS), 2023 | Cardiovascular Malformations | 1st trimester | population based cohort retrospective | unexposed (general population or NOS) excluded | Adjustment: Yes |
1.08 [0.92;1.25] excluded (control group) |
-/11,065 -/6,455,324 | - | 11,065 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S14300 R56357 |
Huybrechts (Controls unexposed, sick), 2023 | Cardiovascular Malformations | 1st trimester | population based cohort retrospective | unexposed, sick | Adjustment: Yes | 1.08 [0.91;1.29] | -/8,350 -/318,731 | - | 8,350 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Total | 2 studies | 1.09 [0.92;1.29] | 142 | 8,519 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives |
1: Controls unexposed, sick; 2: Controls unexposed, sick;
Funnel plot not drawn. Less than 3 points.
Asymetry test p-value = NaN (by Egger's regression)
not enought points
Funnel plot not drawn. Less than 3 points.
excluded 14301, 18398, 18341