Quetiapine updated on 06-10-2025

Respiratory system anomalies

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S12149
R45006		 Ellfolk (Controls exposed to FGA), 2021 Respiratory tract malformations (ICD-9; 748) 1st trimester population based cohort retrospective exposed to other treatment, sick excluded Adjustment: No 0.08 [0.00;1.64] C
excluded (control group) 		0/2,618   2/1,030 2 2,618
ref
S12147
R44988		 Ellfolk (Controls unexposed NOS), 2021 Respiratory tract malformations (ICD-9; 748) 1st trimester population based cohort retrospective unexposed (general population or NOS) Adjustment: No Matched 0.21 [0.01;3.47] C 0/2,618   20/22,540 20 2,618
ref
Total 1 studies 0.21 [0.01;3.47] 20 2,618
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Ellfolk (Controls unexposed NOS), 2021Ellfolk, 2021 1 0.21[0.01; 3.47]202,6180%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: moderateROB mesure: moderateROB reporting: moderate0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed NOS;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.21[0.01; 3.47]202,618 -NAEllfolk (Controls unexposed NOS), 2021 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.21[0.01; 3.47]202,618 -NAEllfolk (Controls unexposed NOS), 2021 1 Tags Adjustment   - No  - No 0.21[0.01; 3.47]202,618 -NAEllfolk (Controls unexposed NOS), 2021 1 MatchedMatched 0.21[0.01; 3.47]202,618 -NAEllfolk (Controls unexposed NOS), 2021 1 All studiesAll studies 0.21[0.01; 3.47]202,618 -NAEllfolk (Controls unexposed NOS), 2021 10.110.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 12149

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) Out of scale0.21[0.01; 3.47]202,618 -NAEllfolk (Controls unexposed NOS), 2021 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls Out of scale0.08[0.00; 1.64]22,618 -NAEllfolk (Controls exposed to FGA), 2021 10.510.01.0