Quetiapine updated on 06-10-2025

Limb defects

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S12149
R45010		 Ellfolk (Controls exposed to FGA), 2021 Musculoskeletal malformations (ICD-9; 754.3–754.8, 755) 1st trimester population based cohort retrospective exposed to other treatment, sick excluded Adjustment: Yes 0.59 [0.24;1.42]
excluded (control group) 		27/2,618   20/1,030 47 2,618
ref
S12147
R44992		 Ellfolk (Controls unexposed NOS), 2021 Musculoskeletal malformations (ICD-9; 754.3–754.8, 755) 1st trimester population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes Matched 0.67 [0.38;1.19] 27/2,618   234/22,540 261 2,618
ref
Total 1 studies 0.67 [0.38;1.19] 261 2,618
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Ellfolk (Controls unexposed NOS), 2021Ellfolk, 2021 1 0.67[0.38; 1.19]2612,6180%ROB confusion: moderateROB selection: lowROB classification: criticalROB missing: moderateROB mesure: moderateROB reporting: moderate0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed NOS;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.67[0.38; 1.19]2612,618 -NAEllfolk (Controls unexposed NOS), 2021 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.67[0.38; 1.19]2612,618 -NAEllfolk (Controls unexposed NOS), 2021 1 Tags Adjustment   - Yes  - Yes 0.67[0.38; 1.19]2612,618 -NAEllfolk (Controls unexposed NOS), 2021 1 MatchedMatched 0.67[0.38; 1.19]2612,618 -NAEllfolk (Controls unexposed NOS), 2021 1 All studiesAll studies 0.67[0.38; 1.19]2612,618 -NAEllfolk (Controls unexposed NOS), 2021 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 12149

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.67[0.38; 1.19]2612,618 -NAEllfolk (Controls unexposed NOS), 2021 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.59[0.24; 1.44]472,618 -NAEllfolk (Controls exposed to FGA), 2021 10.510.01.0