Quetiapine updated on 06-10-2025

Early intrauterine deaths (< 22 weeks) / Spontaneous abortions

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18357
R77405		 Ishikawa, 2024 Miscarriage (4 - 22 weeks of gestation) during pregnancy (anytime or not specified) nested case control unexposed (general population or NOS) Adjustment: Yes 0.92 [0.65;1.29] 49/191   44,069/176,244 44,118 191
ref
S3894
R8257		 Ozturk, 2016 Miscarriage during pregnancy (anytime or not specified) retrospective cohort unexposed (general population or NOS) Adjustment: No 1.76 [0.09;34.18] C 0/5   15/261 15 5
ref
S2437
R3080		 Sorensen, 2015 Spontaneous abortion (< 22 weeks) early pregnancy population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes 1.65 [1.28;2.15] 42/174   114,314/841,183 114,356 174
ref
S3900
R8269		 Yaris, 2005 Spontaneous abortions during pregnancy (anytime or not specified) prospective cohort unexposed (general population or NOS) Adjustment: No 8.37 [0.32;219.24] C 0/2   9/248 9 2
ref
Total 4 studies 1.32 [0.79;2.22] 158,498 372
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Ishikawa, 2024Ishikawa, 2024 0.92[0.65; 1.29]44,11819145%ROB confusion: seriousROB selection: moderateROB classification: moderateROB missing: criticalROB mesure: moderateROB reporting: moderate Ozturk, 2016Ozturk, 2016 1.76[0.09; 34.18]1553%ROB confusion: criticalROB selection: unclearROB classification: moderateROB missing: lowROB mesure: criticalROB reporting: moderate Sorensen, 2015Sorensen, 2015 1.65[1.28; 2.15]114,35617449%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Yaris, 2005Yaris, 2005 8.37[0.32; 219.24]922%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (4 studies) I2 = 64% 1.32[0.79; 2.22]158,4983720.220.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.67[1.29; 2.16]114,3801810%NAOzturk, 2016 Sorensen, 2015 Yaris, 2005 3 case control studiescase control studies 0.92[0.65; 1.30]44,118191 -NAIshikawa, 2024 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.32[0.79; 2.22]158,49837264%NAIshikawa, 2024 Ozturk, 2016 Sorensen, 2015 Yaris, 2005 4 Tags Adjustment   - No  - No 3.56[0.40; 32.01]2470%NAOzturk, 2016 Yaris, 2005 2   - Yes  - Yes 1.25[0.70; 2.21]158,47436586%NAIshikawa, 2024 Sorensen, 2015 2 All studiesAll studies 1.32[0.79; 2.22]158,49837264%NAIshikawa, 2024 Ozturk, 2016 Sorensen, 2015 Yaris, 2005 40.220.01.0

Publication bias and p-hacking diagnosis

funnel plot
0.0-3.94.21.9990.000Ishikawa, 2024Ozturk, 2016Sorensen, 2015Yaris, 2005

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot
0.01.00.01.0

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.32[0.79; 2.22]158,49837264%NAIshikawa, 2024 Ozturk, 2016 Sorensen, 2015 Yaris, 2005 40.510.01.0