Quetiapine updated on 06-10-2025

Preterm (< 37 weeks)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18403
R77657		 Kananen, 2023 Preterm birth (delivery before the 37th gestational week) during pregnancy (anytime or not specified) retrospective cohort unexposed (general population or NOS) Adjustment: Yes 1.30 [0.80;2.12] 20/152   2,151/35,133 2,171 152
ref
S3894
R8254		 Ozturk, 2016 Preterm birth (<37 weeks) during pregnancy (anytime or not specified) retrospective cohort unexposed (general population or NOS) Adjustment: No 3.10 [0.15;62.41] C 0/5   8/246 8 5
ref
S2456
R3125		 Vigod, 2015 Preterm birth <37 weeks gestation during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed, sick Adjustment: No 1.11 [0.83;1.48] C 87/556   146/1,021 233 556
ref
S2474
R3206		 Newport, 2007 Preterm (<37 weeks estimated gestational age) late pregnancy prospective cohort exposed to other treatment, sick Adjustment: No 1.92 [0.07;51.03] C 1/21   0/13 1 21
ref
Total 4 studies 1.17 [0.91;1.50] 2,413 734
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Kananen, 2023Kananen, 2023 1.30[0.80; 2.12]2,17115226%ROB confusion: seriousROB selection: unclearROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Ozturk, 2016Ozturk, 2016 3.10[0.15; 62.41]851%ROB confusion: criticalROB selection: unclearROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Vigod, 2015Vigod, 2015 1.11[0.83; 1.48]23355673%ROB confusion: unclearROB selection: lowROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Newport, 2007Newport, 2007 1.92[0.07; 51.03]1211%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (4 studies) I2 = 0% 1.17[0.91; 1.50]2,4137340.510.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.17[0.91; 1.50]2,4137340%NAKananen, 2023 Ozturk, 2016 Vigod, 2015 Newport, 2007 4 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.33[0.82; 2.15]2,1791570%NAKananen, 2023 Ozturk, 2016 2 unexposed, sickunexposed, sick 1.11[0.83; 1.48]233556 -NAVigod, 2015 1 exposed to other treatment, sickexposed to other treatment, sick 1.92[0.07; 51.03]121 -NANewport, 2007 1 Tags Adjustment   - No  - No 1.13[0.85; 1.50]2425820%NAOzturk, 2016 Vigod, 2015 Newport, 2007 3   - Yes  - Yes 1.30[0.80; 2.12]2,171152 -NAKananen, 2023 1 All studiesAll studies 1.17[0.91; 1.50]2,4137340%NAKananen, 2023 Ozturk, 2016 Vigod, 2015 Newport, 2007 40.510.01.0

Publication bias and p-hacking diagnosis

funnel plot
0.0-3.94.12.0070.000Kananen, 2023Ozturk, 2016Vigod, 2015Newport, 2007

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot
0.01.00.01.0

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.33[0.82; 2.15]2,1791570%NAKananen, 2023 Ozturk, 2016 2 unexposed, sick controlsunexposed, sick controls 1.11[0.83; 1.48]233556 -NAVigod, 2015 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.92[0.07; 51.03]121 -NANewport, 2007 10.510.01.0